嗜酸性粒细胞在慢性阻塞性肺疾病病情评估和治疗中的指导价值研究进展

Research progress on the guiding value of eosinophils in the assessment and treatment of chronic obstructive pulmonary disease

慢性阻塞性肺疾病(COPD),简称慢阻肺,是一种常见的肺部疾病,其患病率、死亡率逐年增加,造成了庞大的社会经济负担。慢性阻塞性肺疾病急性加重期(AECOPD)事件的发生,使上述情况更加严峻。近年来,人们逐渐认识到慢阻肺是一种异质性疾病,可用表型来描述,嗜酸性粒细胞(EOS)型慢阻肺是目前研究较热的一种表型。EOS可用于评估慢阻肺病人的病情,反映病人全身炎症程度,可作为病人是否使用糖皮质激素治疗的生物标志物,可在一定程度上反映慢阻肺病人的预后。该研究就EOS在慢阻肺疾病中病情评估、指导治疗等方面进行阐述。

Chronic obstructive pulmonary disease(COPD) is a common lung disease whose prevalence and mortality rates are increasing year by year,causing a huge socioeconomic burden.The occurrence of acute exacerbation of chronic obstructive pulmonary disease(AECOPD) events has made the above situation even more severe.In recent years,COPD has been recognized as a heterogeneous disease that can be described by phenotype.The eosinophilic(EOS) type of COPD is one of the more studied phenotypes,and EOS can be used to assess the condition of COPD patients,reflect the degree of systemic inflammation,serve as a biomarker for the use of glucocorticoid therapy,and,to some extent,reflect the prognosis of COPD patients.This study describes the use of EOS in the assessment of disease and guidance of treatment in COPD.