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丁苯酞对轻度缺血性血管性认知障碍合并睡眠障碍病人的疗效 被引量:1

Effect of butylphthalide on patients with mild ischemic vascular cognitive impairment and sleep disturbance
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摘要 目的探讨丁苯酞对轻度缺血性血管性认知障碍(VCI)合并睡眠障碍病人的临床疗效。方法选取2019年1月至2021年1月在石家庄市人民医院神经内科门诊及住院轻度缺血性VCI合并睡眠障碍病人120例作为研究对象。按随机数字表法将其为对照组及治疗组各60例。对照组采用抗血小板聚集、降脂稳定斑块等基础治疗90 d。治疗组在对照组基础上应用丁苯酞,丁苯酞的用法为临床标准剂量,每次0.2 g,3次/日,口服90 d。观察并比较病人治疗前后90 d症状、体征,简易智能精神状态检查量表(MMSE)、蒙特利尔认知评估量表(MOCA)、匹兹堡睡眠质量指数(PSQI)量表、疗效及不良反应。结果两组研究对象的性别、年龄及治疗前各组评分数据差异无统计学意义(P>0.05),具有可比性。治疗组治疗后MMSE评分(22.83±1.84)分、MOCA评分(22.83±1.84)分均高于治疗前(20.27±1.85)分、(21.17±3.18)分(均P<0.05),PSQI量表评分(8.52±3.05)分低于治疗前(16.80±1.81)分(P<0.05)。治疗后,治疗组MMSE评分、MOCA评分较对照组提高(P<0.05),治疗组PSQI睡眠指数较对照组降低(P<0.05)。治疗组显效31例,有效13例,无效16例,对照组显效14例,有效12例,无效34例,两组疗效比较差异有统计学意义(Z=−3.58,P<0.001)。两组用药后均未出现任何不良反应。结论丁苯酞可改善轻度缺血性VCI合并睡眠障碍病人认知功能,改善了生活质量,提高了睡眠质量。 Objective To investigate the clinical effect of butylphthalide on patients with mild ischemic vascular cognitive impairment(VCI)complicated with sleep disorders.Methods From January 2019 to January 2021,120 patients with mild ischemic VCI complicated with sleep disorders in the outpatient and inpatient Department of Neurology of Shijiazhuang People's Hospital were selected as the research objects.According to the random number table method,they were divided into the control group and the treatment group,with 60 cases in each group.The control group was treated with anti-platelet aggregation and lipid-lowering to stabilize plaque for 90 days.On the basis of the control group,the treatment group was treated with butylphthalide 0.2 g once,3 times a day,orally for 90 days.The symptoms,signs,mini-Mental State Examination(MMSE),Montreal Cognitive Assessment(MOCA),Pittsburgh Sleep Quality Index(PSQI),efficacy and adverse reactions were observed and compared before and after 90 days of treatment.Results There were no significant differences in gender,age and scores before treatment between the two groups(P>0.05),which were compara⁃ble.The MMSE score(22.83±1.84)and MOCA score(22.83±1.84)in the treatment group after treatment were significantly higher than those before treatment(20.27±1.85)and(21.17±3.18)(all P<0.05).The PSQI score was(8.52±3.05)lower than that before treatment(16.80±1.81)(P<0.05).After treatment,the MMSE score and MOCA score of the treatment group were higher than those of the control group(P<0.05),and the PSQI sleep index of the treatment group was lower than that of the control group(P<0.05).In the treatment group,31 cases were effective,13 cases were effective and 16 cases were ineffective,while in the control group,14 cases were effective,12 cases were effective and 34 cases were ineffective.The difference in efficacy between the two groups was statistically significant(Z=−3.58,P<0.001).There were no adverse reactions in both groups.Conclusion Butylphthalide can improve cognitive function,quality of life and sleep quality in patients with mild ischemic VCI complicated with sleep disorder.
作者 裴耀华 苏荣英 王晓宇 唐蕊 赵明哲 程凯力 PEI Yaohua;SU Rongying;WANG Xiaoyu;TANG Rui;ZHAO Mingzhe;CHENG Kaili(Department of Neurology,Shijiazhuang People's Hospital,Shijiazhuang,Hebei 050000,China)
出处 《安徽医药》 CAS 2022年第12期2516-2519,共4页 Anhui Medical and Pharmaceutical Journal
基金 2021年度河北省医学科学研究课题计划(20211125)。
关键词 丁苯酞 脑缺血 认知障碍 血管性认知障碍 睡眠障碍 Butylphthalide Brain ischemia Cognition disorders Vascular cognitive impairment(VCI) Sleep disorder
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