连续血液净化治疗儿童脓毒血症的效果观察

Observation on the effect of continuous blood purification in the treatment of sepsis in children

目的 观察连续血液净化治疗儿童脓毒血症的临床效果。方法 27例脓毒血症患儿,按治疗方式不同分为对照组(16例)和观察组(11例)。对照组患儿采用常规治疗方案,观察组患儿在对照组的基础上采用连续血液净化治疗。对比两组患儿的存活率、死亡率及存活患儿治疗后的血清降钙素原(PCT)水平、PCT峰值下降时间、炎症因子水平。结果 观察组患儿存活率72.73%明显高于对照组的31.25%,死亡率27.27%明显低于对照组的68.75%,差异有统计学意义(P<0.05)。观察组存活患儿PCT水平(2.71±0.85)ng/ml明显低于对照组的(8.34±0.91)ng/ml, PCT峰值下降时间(3.25±1.25)d明显短于对照组的(5.56±1.47)d,差异有统计学意义(P<0.05)。观察组存活患儿白细胞介素-6(IL-6)水平(8.72±4.18)pg/ml明显低于对照组的(73.73±20.37)pg/ml,差异有统计学意义(P<0.05)。结论 采用连续血液净化治疗脓毒血症患儿,不仅能提高临床治疗效果,还能改善患儿的PCT与炎症因子水平,有助于促使患儿加快康复,值得临床应用。

Objective To observe the clinical effect of continuous blood purification in the treatment of sepsis in children.Methods A total of 27 children with sepsis were divided into control group(16 cases)and observation group(11 cases)according to different treatment methods.Children in the control group received conventional treatment regimen,and children in the observation group received continuous blood purification on the basis of the control group.Comparison was made on survival rate and mortality rate between the two groups,as well as serum procalcitonin(PCT)level,PCT peak decline time,and inflammatory factor levels of the surviving children after treatment.Results The survival rate in the observation group was 72.73%,which was significantly higher than 31.25%in the control group,and the mortality rate 27.27%was significantly lower than 68.75%in the control group,and the differences were all statistically significant(P<0.05).The PCT level(2.71±0.85)ng/ml of the surviving children in the observation group was significantly lower than(8.34±0.91)ng/ml in the control group,and the PCT peak decline time(3.25±1.25)d was significantly shorter than(5.56±1.47)d in the control group,and the differences were all statistically significant(P<0.05).The interleukin-6(IL-6)(8.72±4.18)pg/ml of the surviving children in the observation group was significantly lower than(73.73±20.37)pg/ml in the control group,and the difference was statistically significant(P<0.05).Conclusion Continuous blood purification for sepsis children can not only improve the clinical effect,but also improve the levels of PCT and inflammatory factors,which is helpful to accelerate the recovery of children,and is worthy of clinical application.