银杏达莫注射液+坎地沙坦酯治疗早期糖尿病肾病的临床效果分析

Analysis of clinical effect of ginkgo leaf extract and dipyridamole injection+candesartan cilexetil in the treatment of early diabetic nephropathy

目的 探究银杏达莫注射液+坎地沙坦酯治疗早期糖尿病肾病的临床疗效及不良反应,为临床医师选择合理用药方案提供参考。方法 196例早期糖尿病肾病患者,按照随机数字表法分为观察组和对照组,每组98例。观察组采用银杏达莫注射液+坎地沙坦酯治疗,对照组仅接受坎地沙坦酯治疗。比较两组患者肾功能指标[肌酐清除率(Ccr)、尿白蛋白排泄率(UAER)]、临床疗效、不良反应发生情况。结果 观察组UAER(66.62±6.55)μg/min低于对照组的(94.37±9.32)μg/min, Ccr(82.67±8.25)ml/min高于对照组的(77.49±7.63)ml/min,差异均有统计学意义(P<0.05)。观察组治疗总有效率为95.92%,高于对照组的87.76%,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 应用银杏达莫注射液+坎地沙坦酯治疗早期糖尿病肾病具有显著的临床效果,并可改善患者的肾功能,安全性较好,建议临床推广。

Objective To investigate the clinical efficacy and adverse reactions of ginkgo leaf extract and dipyridamole injection+candesartan cilexetil in the treatment of early diabetic nephropathy,so as to provide reference for clinicians to choose a rational drug regimen.Methods A total of 196 patients with early diabetic nephropathy were divided into observation group and control group according to the random numerical table,with 98 cases in each group.The observation group was treated with ginkgo leaf extract and dipyridamole injection+candesartan cilexetil,and the control group only received candesartan cilexetil.The renal function indexes[creatinine clearance rate(Ccr),urinary albumin excretion rate(UAER)],clinical efficacy,and occurrence of adverse reactions were compared between the two groups.Results The UAER(66.62±6.55)μg/min of the observation group was lower than(94.37±9.32)μg/min of the control group,and the Ccr(82.67±8.25)ml/min was higher than(77.49±7.63)ml/min of the control group,and the differences were all statistically significant(P<0.05).The total effective rate of the observation group was 95.92%,which was higher than 87.76%of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Ginkgo leaf extract and dipyridamole injection+candesartan cilexetil has significant clinical effect in the treatment of early diabetic nephropathy,and can improve the renal function of patients with high safety,which is suggested for clinical promotion.