卵巢癌DCE-MRI定量参数与临床病理的相关性分析

Correlation between DCE-MRI Quantitative Parameters of Ovarian Cancer and Clinicopathology

目的分析卵巢癌动态对比增强磁共振成像(DCE-MRI)定量参数与临床病理的相关性。方法回顾性分析2018年1月至2020年2月在我院治疗的100例卵巢癌患者的临床资料,并以同期健康体检者50例为对照组。比较卵巢癌组及对照组DCE-MRI定量参数[容积转移常数(K^(trans))、血管外细胞外间隙容积比(V_(e))、速率常数(k_(ep))];分析卵巢癌患者的临床病理资料,比较不同卵巢癌患者临床病理的DCEMRI定量参数,并采用Spearson检验分析DCE-MRI定量参数与卵巢癌患者临床病理的相关性分析;采用ROC曲线分析DCE-MRI定量参数对卵巢癌的诊断价值。结果卵巢癌组K^(trans)、V_(e)、k_(ep)值大于对照组(P﹤0.05);组织分级Ⅲ~Ⅳ级的患者K^(trans)、V_(e)、k_(ep)值大于Ⅰ~Ⅱ级,肿瘤体积≥5cm的患者Kep值大于﹤5cm,已出现远处转移者K^(trans)、V_(e)、k_(ep)值大于未出现远处转移者,高、中分化程度患者K^(trans)、V_(e)、k_(ep)值大于低分化者(P﹤0.05);卵巢癌患者K^(trans)、V_(e)、k_(ep)值与组织分级、远处转移及分化程度呈正相关,k_(ep)值与肿瘤大小呈正相关(P﹤0.05);经ROC曲线分析得,K^(trans)、V_(e)、k_(ep)值诊断卵巢癌的AUC分别为0.828、0.899、0.926,截点值分别为0.262min、0.554%、0.437min。结论卵巢癌患者K^(trans)、V_(e)、k_(ep)值与组织分级、远处转移及分化程度呈正相关,且对卵巢癌具有诊断价值。

Objective To analyze the correlation between dynamic contrast enhancement magnetic resonance imaging(DCE-MRI)quantitative parameters of ovarian cancer and clinicopathology.Methods The clinical data of 100 ovarian cancer patients who were treated in the hospital from January 2018to February 2020 were retrospectively analyzed.Another 50 healthy controls in the same period were enrolled as control group.DCE-MRI quantitative parameters[volume transfer constant(K^(trans)),extravascular extracellular volume fraction(Ve),rate constant(kep)]were compared between ovarian cancer group and control group.The clinicopathological data of ovarian cancer patients were analyzed.DCE-MRI quantitative parameters of clinicopathology were compared among different ovarian cancer patients.The correlation between DCE-MRI quantitative parameters andclinicopathology was analyzed by Spearson test.The diagnostic value of DCE-MRI quantitative parameters in ovarian cancer was analyzed by ROC curves.Results K^(trans),Ve and kep in cancer group were greater than those in control group(P﹤0.05).K^(trans),Ve and kep in patients with tissue grading at gradeⅢ-Ⅳwere greater than those atⅠ-Ⅱ.Kep in patients with tumor volume not shorter than 5 cm was greater than that shorter than 5 cm.K^(trans),Ve and kep in patients with distant metastasis were greater than those without distant metastasis.K^(trans),ve and kep in patients with high and moderate differentiation were greater than those with poor differentiation(P﹤0.05).K^(trans),Ve and kep were positively correlated with tissue grading distant metastasis and differentiation degree,kep was positively correlated with tumor size(P﹤0.05).ROC curve analysis showed that AUC and cutoff values of K^(trans),Ve and kep for diagnosis of ovarian cancer were(0.828,0.899,0.926)and(0.262min,0.554%,0.437min),respectively.Conclusion K^(trans),Veand kep are positively correlated with tissue grading,distant metastasis and differentiation degree in patients with ovarian cancer,which are of diagnostic value for ovarian cancer.