^(18)F-N a F及^(18)F-FDG PET/CT显像对动脉粥样硬化易损斑块的诊断价值

The Diagnostic Value of ^(18)F-NaF and ^(18)F-FDG PET/CT Imaging in Atherosclerotic Vulnerable Plaque

目的探讨^(18)F-NaF及^(18)F-FDG PET/CT用于动脉粥样硬化易损斑块检测的可行性及临床应用价值。方法按纳入标准选取我院心内科患者35例,分别行^(18)F-NaF及^(18)F-FDG PET/CT显像,对显像结果进行t检验。将患者分为心绞痛组与非心绞痛组,对其代谢参数进行秩和检验,统计OCT结果。结果临床资料中腰围在^(18)F-NaF PET/CT显像中阳性组高于阴性组,二者有统计学差异(P=0.014)。在^(18)F-NaF及^(18)F-FDG显像中,冠脉斑块SUV_(max)及TBR在显像阳性组高于阴性组,二者有统计学差异(P﹤0.05)。^(18)F-Na F显像中,心绞痛组冠脉斑块TBR在显像阳性组高于阴性组,非心绞痛组冠脉斑块SUV_(max)和TBR在显像阳性组高于阴性组,均有统计学差异(P﹤0.05);在^(18)F-FDG显像中,心绞痛组和非心绞痛组中,SUV_(max)和TBR在显像阴性和阳性组无统计学差异(P﹥0.05)。15人于冠脉造影时做了OCT,共诊断易损斑块11处,非易损斑块8处。结论^(18)F-Na F较^(18)F-FDG更有望于成为检测易损斑块的重要分子探针。

Objective To explore the feasibility and clinical application value of ^(18)F-NaF and ^(18)F-FDG PET/CT for atherosclerotic vulnerable plaque visible in patients with coronary heart disease.Methods Select 35patients who were hospitalized in the cardiology department of our hospital.The patients underwent ^(18)F-NaF and ^(18)F-FDG PET/CT imaging respectively.The imaging results were compared by t test.The patients were divided into angina pectoris group and non-angina pectoris group,and their metabolic parameters were tested by rank sum,and OCT results were counted.Results In clinical data,Waist circumferences in positive group were higher than that in negative group in ^(18)F-NaF PET/CT imaging with statistical y different(P=0.014).For ^(18)F-NaF and ^(18)F-FDG imaging,SUV_(max) and TBR of coronary plaque in the imaging positive group were higher than that in negative group with statistically different(P﹤0.05).For ^(18)F-NaF imaging,the TBR of coronary plaques in positive imaging group were statistically higher than that in the negative group for the angina pectoris group;And the SUV_(max) and TBR in positive imaging group were also statistically higher than that in the negative group for the non-angina pectoris group(P﹤0.05);For ^(18)F-FDG imaging,SUV_(max) and TBR had no statistically different between the imaging negative and positive groups in the angina group and the non-angina group(P﹥0.05).There were 15people underwent OCT during coronary angiography.A total of 11 vulnerable plaques and 8 nonvulnerable plaques were diagnosed.Conclusion Compared with ^(18)F-FDG,^(18)F-NaF is more likely to be an important molecule for detecting vulnerable plaques.