Annexin蛋白家族调控病毒复制和抗病毒天然免疫反应的研究进展
Research progress of Annexin protein family regulating virus replication and antiviral innate immune response
摘要
病毒复制一般包括吸附、穿入、脱壳、生物合成及装配与释放5个阶段,Annexin蛋白能够与流感病毒和猪繁殖与呼吸综合征病毒(PRRSV)等病毒编码的蛋白相互作用进而影响病毒吸附、穿入及脱壳等复制过程。天然免疫是机体针对各种病原微生物和异物的侵袭而介导抗病毒免疫反应的第一道防线,其激活依赖于模式识别受体(Pattern-recognition receptors,PRRs)识别病原体保守的分子结构称病原相关分子模式(Pathogen-associated molecular patterns,PAMPs),以激活下游相关信号通路,发挥抵御病原体侵入的功能。
作者
薛梦迪
黄丽
翁长江
XUE Meng-di;HUANG Li;WENG Chang-jiang
出处
《中国预防兽医学报》
CAS
CSCD
北大核心
2022年第9期1014-1019,共6页
Chinese Journal of Preventive Veterinary Medicine
基金
国家自然科学基金(31941002)。
参考文献2
-
1刘小辉,彭小东,胡珍珍,赵清梅,何建,黎军和,钟小军.Effects of Over-expression of ANXA10 Gene on Proliferation and Apoptosis of Hepatocellular Carcinoma Cell Line HepG2[J].Journal of Huazhong University of Science and Technology(Medical Sciences),2012,32(5):669-674. 被引量：1
-
2马勇,包红梅,王文超,孙佳善,赵玉辉,王秀荣,陈化兰.禽流感病毒NS1蛋白与ANXA2蛋白相互作用的研究[J].中国预防兽医学报,2015,37(12):899-902. 被引量：1
二级参考文献13
-
1Hale B G, Randall R E, Ortín J, et al. The multifunctional NS1 protein of influenza A viruses [J]. J Gen Virol, 2008, 89(10): 2359-2376.
-
2Wolff T, Ludwig S. Influenza viruses control the vertebrate type I interferon system: factors, mechanisms, and consequences [J]. J Interferon Cytokine Res, 2009, 29(9): 549-558.
-
3Wang Xiao-du, Shen Yang, Qiu Ya-feng et al. The non-structural (NS1) protein of influenza A virus associates with p53 and inhibits p53-mediated transcriptional activity and apoptosis[J]. Biochem Biophy Res Commun, 2010, 395(1): 141-145.
-
4Hayes M J, Shao Dong-min. Regulation of actin dynamics by annexin 2 [J]. EMBO J, 2006, 25(9): 1816-1826.
-
5LeBouder F, Morello E. Annexin II incorporated into influenza virus particles supports virus replication by converting plasminogen into plasmin [J]. J Virol, 2008, 82(14): 6820-6828.
-
6Zhu Zi-xiang, Shi Zi-xue, Yan Wen-jun, et al. Nonstructural protein 1 of influenza A virus interacts with human guanylate-binding protein 1 to antagonize antiviral activity [J]. PLoS One, 2013, 8(2): e55920.
-
7Kazuki T, Van P. Quantitative proteomic analysis of the influenza A virus nonstructural proteins NS1 and NS2 during natural cell infection identifies PACT as an NS1 target protein and antiviral host factor [J]. J Virol, 2014, 88(16): 9038-9048.
-
8Hrincius E R, Liedmann S, Anhlan D, et al. Avian influenza viruses inhibit the major cellular signalling integrator c Abl [J]. Cellular Microbiol, 2014, 16(12): 1854-1874.
-
9Gack M U, Albrecht R A. Influenza A virus NS1 targets the ub- iquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I [J]. Cell Host Microbe, 2009, 5(5): 439-449.
-
10Li Jian-gnan, Guo Dong-wei, Huang Li, et al. The interaction between host Annexin A2 and viral Nsp9 is beneficial for replication of porcine reproductive and respiratory syndrome virus [J]. Virus Res, 2014, 189: 106-113.
-
1Akiko Sakai,Hideaki Matsui.Cellular response against cytosolic leakage of mitochondrial DNA: insights into the pathology of Parkinson’s disease[J].Neural Regeneration Research,2022,17(12):2682-2684.
-
2钟波,舒红兵.天然免疫关键信号蛋白MITA的发现及其意义[J].中国科学：生命科学,2022,52(9):1399-1406.
-
3贾鑫,王遥,张美琦,成翠芹.抗病毒天然免疫信号通路[J].药物评价研究,2022,45(9):1715-1715. 被引量：4
-
4Haili Zhang,Jingbo Huang,Yumeng Song,Xingqi Liu,Meichen Qian,Pei Huang,Yuanyuan Li,Ling Zhao,Hualei Wang.Regulation of innate immune responses by rabies virus[J].Animal Models and Experimental Medicine,2022,5(5):418-429. 被引量：4
-
5Haipeng Liu,Fei Wang,Yajuan Cao,Yifang Dang,Baoxue Ge.The multifaceted functions of cGAS[J].Journal of Molecular Cell Biology,2022,14(5):16-26. 被引量：1
