Annexin蛋白家族调控病毒复制和抗病毒天然免疫反应的研究进展
Research progress of Annexin protein family regulating virus replication and antiviral innate immune response
摘要
病毒复制一般包括吸附、穿入、脱壳、生物合成及装配与释放5个阶段,Annexin蛋白能够与流感病毒和猪繁殖与呼吸综合征病毒(PRRSV)等病毒编码的蛋白相互作用进而影响病毒吸附、穿入及脱壳等复制过程。天然免疫是机体针对各种病原微生物和异物的侵袭而介导抗病毒免疫反应的第一道防线,其激活依赖于模式识别受体(Pattern-recognition receptors,PRRs)识别病原体保守的分子结构称病原相关分子模式(Pathogen-associated molecular patterns,PAMPs),以激活下游相关信号通路,发挥抵御病原体侵入的功能。
作者
薛梦迪
黄丽
翁长江
XUE Meng-di;HUANG Li;WENG Chang-jiang
出处
《中国预防兽医学报》
CAS
CSCD
北大核心
2022年第9期1014-1019,共6页
Chinese Journal of Preventive Veterinary Medicine
基金
国家自然科学基金(31941002)。
参考文献2
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