药物相关性慢性肝衰竭患者临床特点分析

An analysis on the clinical characteristics of patients with drug-induced chronic liver failure

目的分析药物相关性慢性肝衰竭患者的临床特征。方法回顾性分析2018年1月至2021年6月首都医科大学附属北京佑安医院住院治疗的药物相关性慢性肝衰竭患者的实验室检查结果。结果纳入患者12例,黄疸12例,脾大10例,腹水9例,其中3级腹水4例,2级腹水3例,肝性脑病1例。9例患者伴有中重度贫血,12例患者的血小板均低于100×10^(9)/L,凝血酶原时间均延长3s以上,INR均高于正常参考值上限。ALT为(38.92±39.86)U/L,AST为(78.08±73.58)U/L,DBil为(101.61±78.73)μmol/L,GGT为(37.42±34.28)U/L,ALP为(110.83±40.42)U/L。结论药物相关性慢性肝衰竭患者的肝功能指标均不正常,病情严重,预后差。

Objective To analysis the clinical and laboratory findings of patients with drug-induced chronic liver failure.Methods The laboratory test results of patients with drug-induced chronic liver failure who were hospitalized in Beijing You'an Hospital Affiliated to Capital Medical University from January 2018 to June 2021 were retrospectively analyzed.Results A total of 12 patients were included,with a male to female ratio of 1:11.All patients(100%)had jaundice,10 patients(83.33%)had splenomegaly,9 patients(75%)had ascites,and 4 patients had grade 3 ascites.There were 3 cases of grade 2 ascites and 1 case of hepatic encephalopathy(8.33%).75%of the patients were accompanied by moderate to severe anemia,and the platelet counts of 12 patients were all below 100×10^(9)/L.The prothrombin times of all patients were prolonged by more than 3s,with INR higher than the upper limit of normal reference value.The bilirubin levels were elevated,especially DBil.The patient's ALT,AST,DBil,GGT ALP were(38.92±39.86)U/L,(78.08±73.58)U/L,(101.61±78.73)μmol/L,(37.42±34.28)U/L and(110.83±40.42)U/L,respectively.Conclusion The laboratory indicators and clinical characteristics of patients with drug-induced chronic liver failure have their own specialties The more serious the disease presents,and the worse of the prognosis.