计算流体力学模拟动态环境下多孔支架结构对成骨细胞的剪切力

Effect of porous cell scaffold structure on fluid shear force of osteoblasts under dynamic culture environment by CFD simulation

传统假体植入物是实心结构,其弹性模量远高于自体骨,植入后易产生应力遮挡效应。为研究假体植入物不同结构对钛合金假体流体剪切力分布的影响,并确定最适合成骨细胞在生理条件下生长的结构,采用SolidWorks软件建立了5种孔隙率相同、结构不同的多孔钛合金假体,并且采用ANSYS Fluent软件对5种假体的比表面积进行比较,建立了假体的流动模型。将各假体表面剪应力的大小和分布与生理条件下的流体剪应力进行比较,确定其一致性。在保持假体结构不变的情况下,通过改变假体的孔隙率得到4种不同的假体,运用计算流体力学软件分析,得到假体表面流体剪应力的分布。将流体剪应力与生理条件下流体剪应力区间进行比较,最终获得了一种最适合细胞生长的多孔钛合金假体的结构。

Traditional prosthetic implant is solid structure and its elastic modulus is much higher than that of autogenous bone.Stress shielding effect highly occurs after implantation.The aim of this paper is to determine the distribution of fluid shear stress on 3D printed metal prostheses with various structures and to determine the most suitable structures under physiological conditions for osteoblasts to grow.In this paper,5 porous 3D printed metal prostheses with the same porosity but various structures were established by SolidWorks.The specific surface areas of 5 kinds of prosthesis were compared using ANSYS Fluent software and the flow models of prosthesis were established.The size and distribution of the surface shear stress of each prosthesis were compared with the fluid shear stress under physiological conditions to determine the consistency.4 different types of prosthesis were obtained by changing the porosity of the prosthesis without changing the structure of the prosthesis.The distribution of fluid shear stress on prosthesis surface was obtained by CFD software analysis.The fluid shear stress was compared with the fluid shear stress range under physiological conditions and the most suitable porous metal prosthesis was obtained.