意向放松训练在抗PD-1单克隆抗体治疗晚期肺癌患者中的应用

Application practice of intentional relaxation training in the treatment of advanced lung cancer patients with anti PD-1 monoclonal antibody

目的 探究意向放松训练在抗PD-1单克隆抗体治疗晚期肺癌患者中的应用。方法 选取医院2018年8月—2021年8月收治的抗PD-1单克隆抗体治疗晚期肺癌患者158例为研究对象,按照组间基本特征具有可比性的原则将其分为观察组与对照组,每组79例。对照组行常规护理,观察组加用意念放松训练。比较两组心理状态、癌因疲乏、生活质量。结果 干预前,两组心理状态各项评分比较差异无统计学意义(P>0.05);干预后,观察组心理状态各项评分均高于对照组,差异有统计学意义(P<0.05)。干预前,两组癌因疲乏各项评分比较差异无统计学意义(P>0.05);干预后,观察组癌因疲乏各项评分均低于对照组,差异有统计学意义(P<0.05)。干预前,两组生活质量各项指标评分比较差异无统计学意义(P>0.05);干预后,观察组生活质量各项指标均优于对照组,差异有统计学意义(P<0.05)。结论意向放松训练可以改善在抗PD-1单克隆抗体治疗晚期肺癌心理状态,降低癌因性疲乏,并提高生活质量。

Objective To explore the application of intentional relaxation training in the treatment of advanced lung cancer patients with anti PD-1 monoclonal antibody. Methods To select 158 patients with advanced lung cancer treated with anti PD-1 monoclonal antibody from August 2018 to August 2021 in the hospital were selected as the study object, and they were divided into an observation group and a control group according to the principle of comparability of basic characteristics between groups, with 79 cases in each group. The control group received routine nursing, while the observation group received mental relaxation training. The psychological status, cancerrelated fatigue and quality of life of the two groups were compared. Results Before the intervention, there was no significant difference in the scores of psychological state between the two groups(P>0.05). After the intervention,the scores of psychological state in the observation group were higher than those in the control group, and the differences were statistically significant(P<0.05). Before the intervention, there was no significant difference in the scores of cancer-related fatigue between the two groups(P>0.05). After the intervention, the scores of cancerrelated fatigue in the observation group were lower than those in the control group, and the differences were statistically significant(P<0.05). Before the intervention, there was no significant difference in the indicators scores of quality of life between the two groups(P>0.05). After the intervention, the indicators scores of quality of life in the observation group were better than those in the control group, and the differences were statistically significant(P<0.05). Conclusion Intentional relaxation training can improve the psychological status of patients with advanced lung cancer treated with anti PD-1 monoclonal antibody, reduce cancer-related fatigue, and improve the quality of life.