天疱疮发病的相关危险因素分析

RISK FACTORS FOR PEMPHIGUS

目的探讨天疱疮发病的相关危险因素。方法选取104例天疱疮病人纳入病例组,143例查体中心体检者纳入对照组,通过回顾性调查对天疱疮的相关危险因素进行分析。结果单因素分析显示,两组食用葱蒜类蔬菜、感染、精神因素、睡眠状况差、接触农药和杀虫剂、外伤及手术、药物摄入、家族史比例等差异有显著意义(χ2=5.620~12.633,P<0.05)。多因素Logistic回归分析显示,食用葱蒜类蔬菜(OR=2.023,95%CI=1.122~3.647,P=0.029)、感染(OR=4.949,95%CI=1.720~14.243,P=0.003)、精神因素(OR=2.883,95%CI=1.408~5.903,P=0.004)、接触农药和杀虫剂(OR=2.048,95%CI=1.026~4.088,P=0.042)、药物摄入(OR=2.904,95%CI=1.147~7.356,P=0.025)、家族史(OR=14.086,95%CI=1.450~136.810,P=0.023)等对天疱疮发病有显著影响。结论食用葱蒜类蔬菜、感染、精神因素、接触农药和杀虫剂、药物摄入及家族史等对天疱疮发病起一定作用。

Objective To investigate the risk factors for pemphigus.Methods A total of 104 patients with pemphigus were enrolled as case group,and 143 individuals who underwent physical examination in the physical examination center were enrolled as control group.A retrospective analysis was performed to analyze the risk factors for pemphigus.Results The univa-riate analysis showed that there were significant differences between the two groups in the intake of onion and garlic vegetables,infection,mental factors,poor sleep status,exposure to pesticides and insecticides,trauma and surgery,drug intake,and proportion of patients with related family history(χ2=5.620-12.633,P<0.05).The multivariate logistic regression analysis showed that intake of onion and garlic vegetables(OR=2.023,95%CI=1.122-3.647,P=0.029),infection(OR=4.949,95%CI=1.720-14.243,P=0.003),mental factors(OR=2.883,95%CI=1.408-5.903,P=0.004),exposure to pesticides and insecticides(OR=2.048,95%CI=1.026-4.088,P=0.04),drug intake(OR=2.904,95%CI=1.147-7.356,P=0.025),and family history(OR=14.086,95%CI=1.450-136.810,P=0.023)had a significant influence on the onset of pemphigus.Conclusion Intake of onion and garlic vegetables,infection,mental factors,exposure to pesticides and insecticides,drug intake,and family history play a certain role in the pathogenesis of pemphigus.