NLR、SII与乳腺癌患者新辅助化疗后病理完全缓解的关系

Relationship between NLR,SII and Pathological Complete Response(pCR)after Neoadjuvant Chemotherapy(NACT)in Breast Cancer Patients

目的分析乳腺癌患者(BC)接受新辅助化疗(NACT)后达到病理完全缓解(pathological complete response,pCR)与淋巴细胞比值(NLR)、系统免疫炎症指标(SII)的关系.方法回顾性分析85例接受NACT的乳腺癌患者的临床资料,根据术后病理Miller-Payne(MP)分级标准判定患者的化疗疗效,即pCR与non-pCR,分析NLR、SII与乳腺癌患者新辅助化疗疗效间的关系.结果85例符合标准的患者19例(22%)患者获得pCR;NLR与淋巴结转移显著相关(P<0.05),与患者年龄、肿瘤直径、HER-2、ER、PR、Ki-67、P53、分子分型、TNM分期无明显相关性(P>0.05);SII与患者年龄、肿瘤直径、淋巴结转移、HER-2、ER、PR、Ki-67、P53、分子分型、TNM分期无明显相关性(P>0.05).相比NLR≥1.99组患者,NLR<1.99组患者有更高的pCR率(P<0.05);相比于SII≥486.8组患者,SII<486.8组患者有更高的pCR率(P<0.05).结论NLR、SII与乳腺癌NACT病理完全缓解存在显著相关性.

Objective To analyze the relationship between pathological complete response(pCR),neutrophil to lymphocyte ratio(NLR)and systemic immune inflammatory index(SII)after neoadjuvant chemotherapy(NACT)in breast cancer(BC)patients.Method Clinic pathological data of 85 breast cancer patients receiving NACT were retrospectively collected.Results pCR was obtained in 19(22%)of 85 patients who met the criteria.NLR was significantly associated with lymph node metastasis(P<0.05),there was no significant correlation with patients’age,tumor diameter,HER-2,ER,PR,Ki-67,P53,molecular typing and TNM stage(P>0.05);There was no significant correlation between SII and patients’age,tumor diameter,lymph node metastasis,HER-2,ER,PR,Ki-67,P53,molecular typing and TNM stage(P<0.05).Compared with patients with NLR≥1.99,patients with NLR<1.99 had higher pCR rate(P>0.05);Compared with patients with SII≥486.8,patients with SII<486.8 had higher pCR rate(P<0.05).Conclusion NLR and SII are significantly correlated with pathological complete response of NACT in breast cancer.