针刺配合黄芪八正散治疗非淋菌性尿道炎的疗效观察及对患者免疫因子的调节作用

Efficacy of Acupuncture Combined with Huang Qi Ba Zheng San in Treating Non-gonococcal Urethritis and Its Regulatory Effects on Immune Factors in the Patients

目的观察针刺配合黄芪八正散治疗非淋菌性尿道炎(NGU)的临床疗效,并探讨其对患者机体免疫状态的调节作用。方法将100例女性NGU患者随机分为研究组和对照组,每组50例。对照组予口服阿奇霉素治疗,研究组予针刺配合中药黄芪八正散治疗。观察两组治疗前后血清中免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、免疫球蛋白A(IgA)及宫颈分泌物中分泌型免疫球蛋白A(SlgA)、干扰素-γ(IFN-γ)的水平变化,并比较两组临床疗效、不良反应发生率、治疗后1个月病原菌转阴率和治疗后3个月复发率。结果研究组总有效率为94.0%,对照组为80.0%,两组比较差异有统计学意义(P<0.05)。治疗后,两组血清中IgG、IgM、IgA水平及宫颈分泌物中SlgA、IFN-γ含量较治疗前升高(P<0.05),研究组高于对照组(P<0.05)。研究组病原菌转阴率高于对照组(P<0.05),复发率低于对照组(P<0.05)。研究组不良反应率明显低于对照组(P<0.05)。结论针刺配合黄芪八正散治疗NGU疗效显著,可有效清除病原菌,提升患者免疫因子水平,降低不良反应率和复发率,优于常规抗生素治疗。

Objective To observe the clinical efficacy of acupuncture combined with Huang Qi Ba Zheng San in the treatment of non-gonococcal urethritis(NGU)and to investigate its regulatory effects on the immune status of patients.Method One hundred female patients with NGU were randomly divided into a study group and a control group,with 50 cases in each group.The control group was treated with oral Azithromycin,while the study group was treated with acupuncture and herbal medicine Huang Qi Ba Zheng San.The levels of immunoglobulin G(IgG),immunoglobulin M(IgM),immunoglobulin A(IgA)in the serum and secretory immunoglobulin A(SlgA)and interferon-γ(IFN-γ)in the cervical secretion were observed before and after treatment in both groups,and the clinical efficacy,incidence of adverse reactions,pathogenic bacteria conversion rate at 1 month after treatment,and the recurrence rate at 3 months after treatment were compared between the two groups.Result The total effective rate was 94.0%in the study group and 80.0%in the control group,with a statistically significant difference between the two groups(P<0.05).After treatment,the levels of IgG,IgM,and IgA in the serum and SlgA and IFN-γin the cervical secretion in both groups were higher than those before treatment(P<0.05)and were higher in the study group than in the control group(P<0.05).The pathogenic bacteria conversion rate was higher in the study group than in the control group(P<0.05).The recurrence rate was lower in the study group than in the control group(P<0.05).The rate of adverse reactions was significantly lower in the study group than in the control group(P<0.05).Conclusion Treatment of NGU with acupuncture and Huang Qi Ba Zheng San is highly effective and is superior to conventional antibiotic treatment;it can remove pathogenic bacteria,improve immune factor levels,and reduce the rates of adverse reactions and recurrence.