主客原络配穴针刺配合常规针刺治疗肾精亏虚型耳鸣的疗效观察及对血清sVCAM-1、ICAM-1水平的影响

Observations on the Efficacy of Primary(Yuan)-connecting(Luo)Point Combination Acupuncture plus Conventional Acupuncture for Tinnitus of Kidney Essence Deficiency Type and its Effect on Serum sVCAM-1 and ICAM-1 Levels in the Patients

目的观察主客原络配穴针刺配合常规针刺治疗肾精亏虚型耳鸣的临床疗效及对血清可溶性血管细胞黏附分子-1(sVCAM-1)和细胞间黏附分子-1(ICAM-1)水平的影响。方法将98例肾精亏虚型耳鸣患者随机分为研究组和对照组,每组49例。对照组给予常规针刺治疗,研究组在对照组基础上采用主客原络配穴法针刺治疗。观察两组治疗前后中医证候积分、不同频率纯音测听值及气导平均听阈值、耳鸣残疾评估量表(THI)、血清氧化应激指标[总抗氧化能力(T-AOC)、谷胱甘肽过氧化物酶(GSH-Px)和超氧化物歧化酶(SOD)]、sVCAM-1和ICAM-1水平变化,并比较两组临床疗效。结果研究组总有效率为91.8%,高于对照组的81.6%(P<0.05)。两组治疗后中医证候积分、不同频率纯音测听值及气导平均听阈值水平、THI评分、血清sVCAM-1和ICAM-1水平较治疗前降低(P<0.05),且研究组低于对照组(P<0.05);两组治疗后血清T-AOC、GSH-Px和SOD水平较治疗前升高(P<0.05),且研究组高于对照组(P<0.05)。结论主客原络配穴针刺配合常规针刺可降低耳鸣症状,下调血清sVCAM-1和ICAM-1水平,减轻氧化应激反应,改善听力。

Objective To observe the clinical efficacy of primary(Yuan)-connecting(Luo)point combination acupuncture plus conventional acupuncture for tinnitus of kidney essence deficiency type and its effect on serum soluble vascular cell adhesion molecule-1(sVCAM-1)and intercellular adhesion molecule-1(ICAM-1)levels in the patients.Method Ninety-eighty patients with tinnitus of kidney essence deficiency type were randomized to study and control groups,with 49 cases in each group.The control group received conventional acupuncture and the study group,primary(Yuan)-connecting(Luo)point combination acupuncture in addition.The TCM syndrome score,pure tone auditory thresholds at different frequencies and mean air conduction auditory threshold,the tinnitus handicap inventory(THI)score and serum oxidative stress indicators(total antioxidant capacity(T-AOC),glutathione peroxidase(GSH-Px)and superoxide dismutase(SOD),sVCAM-1 and ICAM-1 levels were observed in the two groups before and after treatment.The clinical therapeutic effects were compared between the two groups.Result The total efficacy rate was 91.8%in the study group,which was higher than 81.6%in the control group(P<0.05).After treatment,the TCM syndrome score,pure tone auditory thresholds at different frequencies and mean air conduction auditory threshold,the THI score and serum sVCAM-1 and ICAM-1 levels decreased in the two groups compared with before(P<0.05)and were lower in the study group than in the control group(P<0.05).After treatment,serum T-AOC,GSH-Px and SOD levels increased in the two groups compared with before(P<0.05)and were higher in the study group than in the control group(P<0.05).Conclusion Primary(Yuan)-connecting(Luo)point combination acupuncture plus conventional acupuncture can relieve tinnitus symptoms,down-regulate serum sVCAM-1 and ICAM-1 levels,reduce oxidative stress response and improve hearing.