针刺联合穴位埋线治疗过敏性鼻炎的疗效观察及对血清炎症因子的影响

Observations on the Efficacy of Acupuncture plus Acupoint Suture Embedding for Allergic Rhinitis and its Effect on Serum Inflammatory Factors

目的观察针刺联合穴位埋线治疗过敏性鼻炎(AR)的临床疗效及对血清炎症因子的影响。方法将86例常年性AR患者随机分为对照组和治疗组,每组43例。对照组予针刺治疗,治疗组予针刺联合穴位埋线治疗。观察两组治疗前后鼻结膜炎生活质量问卷(RQLQ)评分变化,观察两组治疗前、治疗2周后、治疗后血清炎症因子[白介素-6(IL-6)、白介素-8(IL-8)、白介素-10(IL-10)、白介素-17(IL-17)和白介素-25(IL-25)]水平变化,并比较两组临床疗效、复发率及不良反应发生率。结果治疗后,两组RQLQ评分单独项及总分均较治疗前降低(P<0.05),且治疗组明显低于对照组(P<0.05)。治疗2周后,两组血清IL-6、IL-8、IL-17和IL-25水平均较治疗前降低(P<0.05),血清IL-10水平较治疗前升高(P<0.05)。治疗后,两组血清IL-6、IL-8、IL-17和IL-25水平均较治疗前、治疗2周后降低(P<0.05),且治疗组低于对照组(P<0.05);两组血清IL-10水平均较治疗前、治疗2周后升高(P<0.05),且治疗组高于对照组(P<0.05)。治疗组总有效率为93.0%,显著高于对照组的76.7%(P<0.05)。治疗后3个月治疗组复发率为5.0%,与对照组的15.2%比较,差异无统计学意义(P>0.05);治疗后6个月治疗组复发率为10.0%,显著低于对照组的33.3%(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论针刺联合穴位埋线治疗过敏性鼻炎效果显著,可降低血清IL-6、IL-8、IL-17和IL-25水平,升高血清IL-10水平,减少复发。

Objective To observe the clinical efficacy of acupuncture plus acupoint suture embedding for allergic rhinitis(AR)and its effect on serum inflammatory factors.Method Eighty-six perennial AR patients were randomized to control and treatment groups,with 43 cases in each group.The control group received acupuncture and the treatment group,acupoint suture embedding in addition.The rhinoconjunctivitis quality of life questionnaire(RQLQ)score was recorded in the two groups before and after treatment.Serum inflammatory factors[interleukin-6(IL-6),interleukin-8(IL-8),interleukin-10(IL-10),interleukin-17(IL-17)and interleukin-25(IL-25)]were measured in the two groups before and after two and four weeks of treatment.The clinical therapeutic effects,the recurrence rates and the incidences of adverse reactions were compared between the two groups.Result After treatment,the RQLQ item scores and total score decreased in the two groups compared with before(P<0.05)and were significantly lower in the treatment group than in the control group(P<0.05).After two weeks of treatment,serum IL-6,IL-8,IL-17 and IL-25 levels decreased(P<0.05)and IL-10 increased in the two groups compared with before(P<0.05).After the completion of treatment,serum IL-6,IL-8,IL-17 and IL-25 levels decreased in the two groups compared with before and after two weeks of treatment(P<0.05)and were lower in the treatment group than in the control group(P<0.05);serum IL-10 levels increased in the two groups compared with before and after two weeks of treatment(P<0.05)and were higher in the treatment group than in the control group(P<0.05).The total efficacy rate was 93.0%in the treatment group,which was significantly higher than 76.7%in the control group(P<0.05).At three months after treatment,the recurrence rate was 5.0%in the treatment group and 15.2%in the control group with no statistically significant difference(P>0.05).At six months after treatment,the recurrence rate was 10.0%in the treatment group,which was significantly lower than 33.3%in the control group(P<0.05).The incidence of adverse reactions had no statistically significant difference between the two groups of patients(P>0.05).Conclusion Acupuncture plus acupoint suture embedding has a marked effect in treating allergic rhinitis.It can decrease serum IL-6,IL-8,IL-17 and IL-25 levels,increase IL-10 levels and reduce recurrence.