肠道菌群与慢性阻塞性肺疾病的相关性

Correlation Between Intestinal Flora and Chronic Obstructive Pulmonary Disease

慢性阻塞性肺疾病(COPD)是一种普遍存在的具有社会意义的疾病。它的发生发展涉及多方面因素,但是目前机制并不明确。微生物组研究的最新进展使人们发现微生物群的改变与COPD间的关系。连接肺部和肠道的代谢和免疫轴在COPD的发病机制中起着重要作用。此外,肠道黏膜屏障破坏及肠道代谢物短链脂肪酸(SCFA)等可能参与COPD病程的进展。目前对COPD与肠道菌群的研究仍处于起步阶段,对因果关系和潜在机制的研究很少,这阻碍了制定精确的基于菌群的临床干预措施。对肠道菌群的研究有助于研究COPD的发病机制并探索治疗疾病的新方法。

Chronic obstructive pulmonary disease(COPD)is a prevalent disease with social significance.It’s occurrence and development involve many factors,but the mechanism is not clear at present.Recent advances in microbiome research have led to the discovery of a relationship between changes in the microbiome and COPD.The presence of metabolic and immune axes connecting the lung and intestinal tract plays an important role in the pathogenesis of COPD.In addition,intestinal mucosal barrier destruction and short chain fatty acid(SCFA)of intestinal metabolite may be involved in the course of COPD.Current research on COPD and gut microbiota is still in its infancy,with little understanding of causality and potential mechanisms,hindering the development of precise microbium-based clinical interventions.The study of intestinal flora is helpful to study the pathogenesis of COPD and explore new ways to treat the disease.