^(18)F-FDG PET/CT代谢参数联合血清FOXM1在诊断结直肠癌淋巴结转移中的应用

Application of ^(18)F-FDG PET/CT Metabolic Parameters Combined with Serum FOXM1 in the Diagnosis of Lymph Node Metastasis in Colorectal Cancer

本研究探讨^(18)F-氟代脱氧葡萄糖(FDG)正电子发射/计算机断层显像(PET/CT)代谢参数联合血清叉头盒蛋白M1(FOXM1)诊断结直肠癌淋巴结转移的价值。共纳入103例结直肠癌患者进行研究,通过病理学检查确诊是否发生淋巴结转移,然后将患者分为转移组(51例)和非转移组(52例)。所有患者均进行^(18)F-FDG PET/CT检查,获取最大标准化摄取值(SUVmax)、糖酵解总量(TLG)和肿瘤代谢体积(MTV)三项代谢参数。此外,通过ELISA法检测患者血清FOXM1水平。结果显示,非转移组的SUVmax显著高于转移组(P<0.001)。非转移组的MTV、TLG显著低于转移组(P<0.001)。非转移组的血清FOXM1显著低于转移组(P<0.001)。血清FOXM1与SUVmax显著负相关(P<0.01),而与MTV和TLG显著正相关(P<0.01)。SUVmax+MTV+TLG+血清FOXM1诊断淋巴结转移的AUC(0.974)和敏感性(92.16%)高于^(18)F-FDG PET/CT代谢参数和血清FOXM1的单独诊断,特异性(94.23%)仅低于TLG单独诊断。^(18)F-FDG PET/CT三项代谢参数(SUVmax、MTV及TLG)联合血清FOXM1诊断淋巴结转移的价值较高。

This study investigated the value of ^(18)F-fluorodeoxyglucose(FDG)positron emission/computed tomography(PET/CT)metabolic parameters combined with serum forkhead box protein M1(FOXM1)in the diagnosis of lymph node metastasis of colorectal cancer.A total of 103 patients with colorectal cancer were included in this study,and the lymph node metastasis was confirmed by pathological examination,and then the patients were divided into the metastasis group(51 cases)and the non-metastasis group(52 cases).All patients underwent ^(18)F-FDG PET/CT examination,and then three metabolic parameters of maximum normalized uptake value(SUVmax),total glycolysis(TLG)and tumor metabolic volume(MTV)were obtained.In addition,serum FOXM1 levels of patients were detected by the ELISA method.The results showed that the SUVmax of non-metastasis was significantly higher than that of metastasis group(P<0.001).The MTV and TLG of the non-metastatic group was significantly lower than that of the metastatic group(P<0.001).Serum FOXM1 in the non-metastatic group was significantly lower than that in the metastatic group(P<0.001).Serum FOXM1 was significantly negatively correlated with SUVmax(P<0.01),while significantly positively correlated with MTV and TLG(P<0.01).The AUC(0.974)and sensitivity(92.16%)of SUVmax+MTV+TLG+serum FOXM1 in the diagnosis of lymph node metastasis were higher than those of ^(18)F-FDG PET/CT metabolic parameters and serum FOXM1 alone,and the specificity(94.23%)was only lower than that of TLG alone.The three metabolic parameters(SUVmax,MTV and TLG)of ^(18)F-FDG PET/CT combined with serum FOXM1 have high value in the diagnosis of lymph node metastasis.