摘要
目的:在一系列温度(283.15~323.15 K)下测定硫唑嘌呤在摩尔分数为0.0~1.0的乙醇溶液中的溶解度。方法:用高效液相色谱法测定硫唑嘌呤在乙醇溶液中的溶解度。结果:硫唑嘌呤在乙醇溶液中的溶解度随温度升高而升高;随乙醇浓度升高而先升后降。结论:硫唑嘌呤在乙醇溶液中的溶解度受到温度和乙醇浓度的影响,可使用经验方程计算一定条件下的溶解度。
Objective:The solubilities of azathioprine in different concentrations of ethanol-water solution at the mole fraction of ethanol of 0.0~1.0 at 283.15~323.15 K.Methods:The solubilities of azathioprine in ethanolwater solution were measured by using high-performance liquid chromatography(HPLC).Results:The solubility of azathioprine in ethanol solution increases with increasing temperature;with the increase of ethanol concentration,it increased first and then decreased.Conclusion:The solubility of azathioprine in ethanol solution is affected by temperature and ethanol concentration,and the solubility under certain conditions can be calculated using an empirical equation.
作者
蒋茜
JIANG Qian(Zhaotong Center for Disease Control and Prevention,Zhaotong 657000,China)
出处
《生物化工》
2022年第5期122-124,共3页
Biological Chemical Engineering
