摘要
代谢重编程被认为是肿瘤细胞最重要的特征之一。微小RNAs(microRNAs)是一组多功能的非编码RNA,通过脂质代谢重编程在肝细胞癌(HCC)的发生发展中发挥重要作用。本文综述了microRNAs调控肝癌脂质代谢重编程的研究进展。
Metabolic reprogramming is considered to be one of the top characteristics of tumor cells.Ample experimental studies have shown that microRNAs,which are a group of multifunctional non-coding RNAs,play an important role in the development of hepatocellular carcinoma(HCC)through lipid metabolic reprogramming.The current review briefly introduces the recent progress of specific microRNAs targeting at lipid metabolic reprogramming in HCC,which may provide a potential strategy for clinical targeting tumor therapy.
作者
王玉敏
陈济超
王洪权
王金华
唐博
WANG Yu-min;CHEN Ji-chao;WANG Hong-quan;WANG Jin-hua;TANG Bo(Department of Respiratory and Critical Care Medicine,Aerospace Center Hospital,Peking University Aerospace School of Clinical Medicine,Beijing 100049;Department of Pancreatic Cancer,Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cancer,Key Laboratory of Cancer Prevention and Therapy,Tianjin's Clinical Research Center for Cancer,Tianjin 300060;State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,CAMS&PUMC,Beijing Key Laboratory of Drug Target and Screening Research,Beijing 100050,China)
出处
《基础医学与临床》
2022年第12期1930-1934,共5页
Basic and Clinical Medicine
基金
国家自然科学基金(81871938)
北京市海淀区卫生健康发展科研培育计划(HP2021-19-50701)
航天中心医院院级课题(YN202104)
中国航天科工集团课题(2020-LCYL-009)
航天医科科研课题(2020YK02)。
关键词
肝细胞癌
微小RNAS
脂代谢重编程
肿瘤发生
hepatocellular carcinoma
microRNAs
lipid metabolic reprogramming
tumorigenesis
