FOXM1、mTOR在宫颈癌中的表达及临床意义

Expression and Significance of FOXM1 and mTOR in Cervical Cancer

目的:分析叉头转录因子M1蛋白(FOXM1)、哺乳动物雷帕霉素靶蛋白(mTOR)在宫颈癌组织及癌旁组织中的表达及临床意义。方法:回顾性分析行手术切除的73例宫颈癌患者临床资料,对宫颈癌组织及癌旁组织进行病理学检查,以免疫组化法检测FOXM1、mTOR,比较宫颈癌组织及癌旁组织FOXM1阳性率、mTOR水平,分析与病理结果一致性,并对比不同临床病理参数表达情况。结果:宫颈癌组织FOXM1、mTOR阳性率高于癌旁组织(P<0.05);以宫颈癌组织为阳性标本,以癌旁组织为阴性标本,结果显示,mTOR、FOXM1诊断均与病理结果具有较高的一致性;mTOR与分化程度、临床分期有关,而FOXM1与肿瘤直径、分化程度、临床分期、组织学类型均无关。结论:宫颈癌患者FOXM1、mTOR水平呈高表达趋势,对疾病诊断有一定意义。

Objective:To analyze the expression and clinical significance of forkhead transcription factor M1 protein(FOXM1)and mammalian target of rapamycin(mTOR)in cervical cancer tissues and adjacent tissues.Methods:A total of 73 patients with cervical cancer who underwent surgical resection were retrospectively selected as the research subjects.The positive rate of FOXM1 and mTOR level in cervical cancer tissue and adjacent tissue was compared,the consistency with pathological results was analyzed,and the expression of different clinicopathological parameters was compared.Results:The positive rates of FOXM1 and mTOR in cervical cancer tissues were higher than those in adjacent tissues(P<0.05);Taking cervical cancer tissue as the positive specimen and paracancerous tissue as the negative specimen,it was found that the diagnosis of mTOR and FOXM1 was highly consistent with the pathological results;mTOR was related to the degree of differentiation and clinical stage,while FOXM1 was not related to tumor diameter,degree of differentiation,clinical stage and histological type.Conclusion:The levels of FOXM1 and mTOR in patients with cervical cancer show a trend of high expression,which has certain significance for the diagnosis of the disease.