低生糖指数饼干膳食联合利拉鲁肽干预对2型糖尿病合并肥胖患者糖脂代谢的影响

Effects of Low Glycemic Index Biscuits Diet Combined with Liraglutide on Glucolipid Metabolism in Newly Obese Type 2 Diabetes Patients

目的:以新发肥胖2型糖尿病(Diabetes Mellitus Type 2,T2DM)患者为研究对象,探讨低生糖指数(Glycemic Index,GI)饼干膳食联合利拉鲁肽干预对T2DM糖脂代谢的影响。方法:选取新发肥胖T2DM患者90例,随机分为3组,分别为利拉鲁肽组、低GI饼干膳食组、低GI饼干膳食联合利拉鲁肽干预组,每组各30例。比较3组患者在干预前和干预后第4个月肥胖、糖脂代谢等相关指标的变化。结果:干预第4个月后,3组患者的腰臀比(Waist-to-Hip Ratio,WHR)、体质指数(Body Mass Index,BMI)、糖化血红蛋白(Hemoglobin A1c,HbA1c)、甘油三酯(Triglyceride,TG)、总胆固醇(Total Cholesterol,TC)、低密度脂蛋白胆固醇(Low Density Lipoprotein Cholesterol,LDL-C)、高密度脂蛋白胆固醇(High Density Lipoprotein Cholesterol,HDL-C)、空腹血糖(Fasting Blood Glucose,FPG)、胰岛素抵抗指数(Homeostasis Model Assessment of Insulin Resistance,HOMA-IR)和胰岛β细胞功能指数(Homeostasis Model Assessment-β,HOMA-β)等指标均有明显改善,且低GI饼干膳食联合利拉鲁肽干预组各指标的改善程度均显著优于利拉鲁肽组和低GI饼干膳食组(P<0.05)。结论:低GI饼干膳食联合利拉鲁肽干预具有改善新发肥胖T2DM患者肥胖、糖脂代谢等多种作用,且其效果优于单独低GI饼干膳食干预或利拉鲁肽干预。

Objective:To investigate the effects of low glycemic index(GI)biscuits diet and liraglutide on glucolipid metabolism in newly obese type 2 diabetes mellitus(T2DM)patients.Method:A total of 90 newly diagnosed obese T2DM patients were randomly divided into three groups:liraglutide group,low GI biscuits diet group and their combined intervention group.There were 30 cases in each group.The three groups of patients were treated for 4 months continuously.It is compared that obesity,glucose and lipid metabolism,and other related indexes in the three groups of patients before and after treatment.Result:After four months of intervention,the levels of waist to hip ratio(WHR),body mass index(BMI),hemoglobin A1c(HbA1c),triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),fasting blood glucose(FPG),homeostasis model assessment of insulin resistance(HOMA-IR),and homeostasis model assessment-β(HOMA-β)were significantly improved in all patients after treatment for 4 months.The improvement degree of these parameters in low GI biscuits diet combined with iraglutide group was significantly better than those in the liraglutide group and low GI biscuits diet group(P<0.05).Conclusion:Low GI biscuits diet combined with liraglutide intervention could improve glucose and lipid metabolism,obesity,and other effects in newly obese T2DM patients,and its effect was better than those of low GI biscuits diet intervention or liraglutide intervention alone.