补充性肠外营养联合肠内营养对鼻咽癌患者免疫功能、人体成分及治疗耐受情况的影响

Effects of supplemental parenteral nutrition combined with enteral nutrition on immune function,body compositions and treatment tolerance of patients with nasopharyngeal carcinoma

目的探究补充性肠外营养(SPN)联合肠内营养(EN)对鼻咽癌患者免疫功能、人体成分及治疗耐受情况的影响。方法选取2018年12月至2020年12月我院收治的64例鼻咽癌患者作为研究对象,按照随机数字表法将其分为对照组和研究组,各32例。对照组给予EN,研究组给予SPN联合EN。比较两组的免疫功能、人体成分及治疗耐受情况。结果治疗2周、1个月后,两组白细胞分化抗原3阳性(CD3^(+))、白细胞分化抗原4阳性(CD4^(+))、白细胞分化抗原4阳性/白细胞分化抗原8阳性(CD4^(+)/CD8^(+))均升高,且研究组高于对照组(P<0.05)。治疗前-治疗1周后,两组体重、骨骼肌、体脂肪百分比、身体质量指数(BMI)、体水分、细胞内水分、细胞外水分、蛋白质、无机盐、身体细胞量、矿物质含量比较,差异无统计学意义(P>0.05);治疗前-治疗1个月后,研究组的体重、骨骼肌、体脂肪百分比、BMI、体水分、细胞内水分、细胞外水分、蛋白质、无机盐、身体细胞量、矿物质含量低于对照组,差异具有统计学意义(P<0.05)。治疗1、2周及1个月后,研究组的治疗耐受率高于对照组(P<0.05)。结论SPN联合EN用于鼻咽癌患者中可有效增强免疫功能,减轻人体成分丢失程度,改善治疗耐受情况。

Objective To explore the effects of supplemental parenteral nutrition(SPN)combined with enteral nutrition(EN)on immune function,body compositions and treatment tolerance of patients with nasopharyngeal carcinoma.Methods A total of 64 patients with nasopharyngeal carcinoma admitted in our hospital from December 2018 to December 2020 were selected as the research objects,and the patients were divided into control group and study group according to random number table method,with 32 cases in each group.The control group was given EN,and the observation group was given SPN combined with EN.The immune function,body compositions and treatment tolerance were compared between the two groups.Results After 2 weeks and 1 month of treatment,the cluster of differentiation 3 positive(CD3^(+)),cluster of differentiation 4 positive(CD4^(+))and cluster of differentiation 4 positive/cluster of differentiation 8 positive(CD4^(+)/CD8^(+))in two groups increased,and those in the study group were higher than the control group(P<0.05).Before treatment-after 1 week of treatment,there were no significant differences in the weight,skeletal muscle,body fat percentage,body mass index(BMI),body moisture,intracellular moisture,extracellular moisture,protein,inorganic salts,body cell mass and mineral content between the two groups(P>0.05);before treatment-after 1 month of treatment,the weight,skeletal muscle,body fat percentage,BMI,body moisture,intracellular moisture,extracellular moisture,protein,inorganic salts,body cell mass and mineral content in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After 1,2 weeks and 1 month of treatment,the treatment tolerance rate in the study group was higher than that in the control group(P<0.05).Conclusion SPN combined with EN in patients with nasopharyngeal carcinoma can effectively enhance the immune function,reduce the loss of body compositions and improve the treatment tolerance.