基于“卫气理论”探讨膏脂与血管周围脂肪组织的相关性

Correlation between ointment fat and perivascular adipose tissue based on"Wei-defensive Qi Theory"

卫气与膏脂及血管周围脂肪组织(perivascular adipose tissue,PVAT)在生理、病理上密切相关。PVAT作为脂肪组织,可归属于中医学“膏脂”范畴,在形成、功能、生理、病理等多方面均受卫气影响。基于中医学“卫气理论”及现代研究,首先,卫气与膏脂具有共同的生化来源,膏脂依靠卫气布散精微物质以充养,二者在生理功能上具有一定的相关性;其次,膏脂受卫气调控,PVAT以“气”交感脉中,共同调控血脉,二者均存在类似的昼夜节律;再者,病理上,卫气失常可致膏脂异常,PVAT功能障碍,从而由“脉外至脉内”促使心血管疾病发生发展。故从“卫气理论”切入,探讨膏脂与PVAT相关的内在病理生理机制,从中医学角度为心血管疾病防治提供更多思路。

Wei-defensive qi is closely related to ointment fat and perivascular adipose tissue(PVAT)physiologically and pathologically.PVAT,as adipose tissue,can be classified into the category of"ointment fat"in Chinese medicine,and it is affected by wei-defensive qi in many aspects,such as formation,function,physiology,and pathology.Based on"Wei-defensive Qi Theory"in Chinese medicine and modern research.Wei-defensive qi and ointment fat have originated biochemically the same,and ointment fat relies on wei-defensive qi to disperse fine substances for nourishment.There is a certain correlation between the above two in physiological functions.In addition,ointment fat is regulated by wei-defensive qi,and PVAT regulates blood vessels together with"qi"moving in them.Both of wei-defensive qi and PVAT have similar circadian rhythms.Furthermore,pathologically,the disorder of wei-defensive qi can cause ointment fat dysfunction,PVAT dysfunction,and thus contributed to the development of cardiovascular disease from the"external to internal vessel".Therefore,based on"Wei-defensive Qi Theory",this paper discusses the internal pathophysiological mechanism of ointment fat and PVAT,aiming to provide more ideas for the prevention and treatment of cardiovascular diseases from the perspective of Chinese medicine.