孕酮和β亚单位人绒毛膜促性腺激素对早期先兆流产孕妇保胎结局的影响研究

Effect of Progesterone andβ-subunit Human Chorionic Gonadotrophin on Fetal Preservation Outcomes in Pregnant Women with Early Threatened Abortion

目的探究孕酮(P)和β亚单位人绒毛膜促性腺激素(β-HCG)对早期先兆流产孕妇保胎结局的影响。方法选取81例早期先兆流产孕妇为研究对象,根据其治疗结果分成成功组(39例)与失败组(42例)。分析患者的临床资料,对比两组停经12周时的性激素指标、治疗后临床症状缓解情况和性激素指标阳性情况。并以治疗结果为金标准,计算P、β-HCG联合检验在早期先兆流产孕妇保胎结局的诊断效能。结果停经12周时,成功组P、β-HCG水平高于失败组,差异有统计学意义(P<0.05)。治疗后,成功组腹痛、腰酸、阴道出血等缓解率高于失败组,差异有统计学意义(P<0.05)。治疗后,成功组P、β-HCG阳性率高于失败组,差异有统计学意义(P<0.05)。P、β-HCG联合检验的诊断准确率为91.36%,特异度90.48%,敏感度92.31%,假阳性预测值9.52%,假阴性预测值7.69%。结论P、β-HCG指标水平在预测早期先兆流产孕妇的预后中具有积极作用,尤其是P、β-HCG联合检验在预测早期先兆流产孕妇预后的准确率、特异度、敏感度均较高,建议临床通过上述指标的监测结果调整治疗方案。

Objective To investigate the effect of progesterone(P)andβsubunit human chorionic gonadotropin(β-HCG)on the outcomes of pregnant women with early threatened abortion.Methods 81 pregnant women with early threatened abortion were selected as the research objects,and were divided into success group(39 cases)and failure group(42 cases)according to the treatment results.The clinical data of the patients were analyzed,and the sex hormone indicators at 12 weeks of menopause,the relief of clinical symptoms after treatment and the positive sex hormone indicators were compared between the two groups.Taking treatment outcome as the gold standard,the diagnostic efficacy of P andβ-HCG combined test in early pregnancy with threatened abortion was calculated.Results The levels of P andβ-HCG in the successful group were significantly higher than those in the failed group at 12 weeks of menopause,the differences were statistically significant(P<0.05).After treatment,the remission rates of abdominal pain,lumbar acid and vaginal bleeding in the successful group were higher than those in the failed group,and the differences were statistically significant(P<0.05).After treatment,the positive rates of P andβ-HCG in the successful group were higher than those in the failed group,and the differences were statistically significant(P<0.05).The diagnostic accuracy,specificity,sensitivity,false-positive predictive value and false-negative predictive value of P andβ-HCG combined test were 91.36%,90.48%,92.31%,9.52%and 7.69%,respectively.Conclusion P andβ-HCG index levels play a positive role in predicting the prognosis of pregnant women with early threatened abortion,especially the accuracy,specificity and sensitivity of the combined test of P andβ-HCG in predicting the prognosis of pregnant women with early threatened abortion are high.It is suggested to adjust the treatment plan through the monitoring results of the above indicators.