不同剂量孕激素治疗无排卵型月经不调的临床疗效分析

Clinical Efficacy Analysis of Different Doses of Progesterone in the Treatment of Anovulatory Menstrual Irregularity

目的分析在无排卵型月经不调患者治疗期间应用不同剂量孕激素的临床效果。方法选取96例无排卵型月经不调患者为研究对象,根据治疗方法不同分为研究组与对照组,每组48例。对照组使用大剂量孕激素治疗,研究组使用小剂量孕激素治疗。比较两组治疗效果、不良反应发生情况、生活质量及治疗满意度。结果两组治疗总有效率比较差异无统计学意义(P>0.05)。治疗后,两组生活质量评分均高于治疗前,且研究组生活质量评分高于对照组,差异有统计学意义(P<0.05)。研究组不良反应发生率0低于对照组8.33%,差异有统计学意义(P<0.05)。研究组治疗满意度高于对照组,差异有统计学意义(P<0.05)。治疗后,两组子宫内膜厚度均低于治疗前,但两组子宫内膜厚度比较差异无统计学意义(P>0.05)。结论在无排卵型月经不调患者治疗期间,小剂量孕激素治疗的安全性相对较高,具有良好的临床价值。

Objective To analyze the clinical effect of different doses of progesterone during the treatment of anovulatory menstrual irregularity.Methods A total of 96 patients with anovulatory menstrual irregularity were selected as the research objects.According to the dose,they were divided into the study group and the control group,with 48 cases in each group.The control group was treated with high-dose progesterone,while the study group was treated with low-dose progesterone.The treatment effect,adverse reactions,quality of life and treatment satisfaction were compared between the two groups.Results There was no significant difference in the total effective rate between the two groups(P>0.05).After treatment,the quality of life score of the two groups was higher than that before treatment,and the quality of life score of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the study group was 0 lower than that in the control group 8.33%and the difference was statistically significant(P<0.05).The treatment satisfaction of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the endometrial thickness of the two groups was lower than that before treatment,but there was no significant difference in the endometrial thickness between the two groups(P>0.05).Conclusion Low dose progesterone therapy is relatively safe and has good clinical value in patients with anovulatory menstrual irregularity during treatment.