尿液肝素结合蛋白检测在妊娠期孕妇尿路感染诊断中的价值分析

Analysis of the value of urine heparin-binding protein detection in the diagnosis of urinary tract infection in pregnant women

目的探讨尿液肝素结合蛋白(U-HBP)检测在妊娠期孕妇尿路感染诊断中的临床价值。方法选取128例疑似尿路感染(UTI)的妊娠期孕妇,根据检测结果将孕妇分为UTI组(64例)与非UTI组(64例)。比较两组白细胞酯酶(LEU)、U-HBP、细菌(BACT)、亚硝酸盐(NIT)及尿液白细胞(U-WBC)计数曲线下的面积(AUC)水平及LEU、U-HBP、BACT、NIT和U-WBC诊断UTI的效能。结果UTI组的LEU、U-HBP、BACT、NIT、U-WBC检查结果明显高于非UTI组,差异有统计学意义(P<0.05);LEU、U-HBP、BACT、NIT和U-WBC诊断UTI的AUC及cut-off值分别为0.640、0881、0.815、0.711和0.757及阳性、33 ng/ml、317个/μl、阳性和54个/μl。在诊断UTI时,其中U-HBP相比LEU、BACT、NIT和U-WBC的敏感度、准确率及特异度预测效能更佳,分别为92.2%、89.3%和90.1%。结论U-HBP对妊娠期孕妇早期诊断UTI具有临床价值,值得临床推广与应用。

Objective To investigate the clinical value of urine heparin-binding protein(U-HBP)detection in the diagnosis of urinary tract infection in pregnant women.Methods 128 pregnant women with suspected urinary tract infection(UTI)were selected and divided into UTI group(64 cases)and non-UTI group(64 cases)according to the test results.The area under the curve(AUC)levels of LEU,U-HBP,bacteria(BACT),nitrite(NIT)and urine white blood cell(U-WBC)counts were compared between the two groups,and the diagnostic efficacy of LEU,U-HBP,BACT,NIT and U-WBC was compared between the two groups.Results The results of LEU,U-HBP,BACT,NIT and U-WBC in UTI group were significantly higher than those in non-UTI group(P<0.05).The AUC and cut-off values of LEU,U-HBP,BACT,NIT and U-WBC in the diagnosis of UTI were 0.640,0881,0.815,0.711 and 0.757 and positive,33 ng/ml,317 cells/μl,positive and 54 cells/μl,respectively.The sensitivity,accuracy and specificity of U-HBP were 92.2%,89.3%and 90.1%,respectively,compared with LEU,BACT,NIT and U-WBC in the diagnosis of UTI.Conclusion U-HBP has clinical value in the early diagnosis of UTI in pregnant women,which is worthy of clinical promotion and application.