氨氯地平联合依那普利在老年高血压治疗中的效果

Effect of Amlodipine Combined with Enalapril in the Treatment of Elderly Hypertension

目的观察老年高血压患者采取氨氯地平联合依那普利的治疗效果。方法本文选取2020年8月至2022年8月基层卫生院收治的63例老年高血压患者作为研究对象,按照随机数字表法分组,对照组行氨氯地平治疗,观察组在对照组基础上联合依那普利治疗。结果在治疗前3 d,观察组患者血压水平对比对照组差异无统计学意义(P>0.05),在治疗后3 d,观察组SBP(131.25±6.54)mm Hg、DBP(81.26±5.97)mm Hg、24 h SBP(124.26±5.24)mm Hg、24 h DBP(80.34±4.59)mm Hg低于对照组[(156.85±7.58)、(96.58±6.84)、(130.29±5.21)、(89.67±4.95)mm Hg],差异有统计学意义(P<0.05);在治疗前3 d,观察组睡眠质量以及疼痛评分与对照组比较差异无统计学意义(P>0.05),在治疗后3 d,观察组睡眠质量(5.28±1.01)分、疼痛评分(2.67±0.14)分低于对照组[(12.65±3.27)、(4.24±0.95)分],差异有统计学意义(P<0.05);在治疗前3 d,观察组空腹血糖、糖化血红蛋白、尿蛋白等指标对比对照组无差异(P>0.05),在治疗后3 d,观察组空腹血糖(4.26±1.14)mmol/L、糖化血红蛋白(6.01±0.67)%、尿蛋白(51.64±12.09)mg/L低于对照组[(5.97±1.58)nmol/L、(6.68±0.41)%、(86.57±13.95)mg/L],差异有统计学意义(P<0.05);观察组家庭关系(79.58±5.24)分、生理区间(76.59±5.26)分、精神健康(82.67±5.41)分、躯体疼痛(86.57±4.28)分、社会关系(88.57±6.34)分高于对照组[(63.29±3.16)、(56.24±2.15)、(69.52±4.20)、(64.28±3.04)、(70.05±3.04)分],差异有统计学意义(P<0.05);观察组不良反应5.41%低于对照组的25.00%,差异有统计学意义(P<0.05)。结论针对老年高血压患者,为患者提供氨氯地平联合依那普利的药物治疗方案,能够有效改善患者血压水平,并且能够调整患者睡眠质量,降低患者因为疾病出现的疼痛感,可确保患者血糖水平的稳定性,可进一步改善患者生活质量。

Objective To observe the therapeutic effect of amlodipine combined with enalapril in elderly patients with hypertension.Methods From August 2020 to August 2022,63 elderly patients with hypertension who were admitted to primary health centers were selected as the study objects.They were randomly divided into groups by numerical table.The control group was treated with amlodipine,and the observation group was treated with enalapril.Results Three days before treatment,there was no difference in blood pressure between the observation group and the control group(P>0.05),3 days after treatment,SBP(131.25±6.54)mm Hg,DBP(81.26±5.97)mm Hg,24 hour SBP(130.26±5.24)mm Hg,24 hour DBP(80.34±4.59)mm Hg in the observation group were lower than those in the control group[(156.85±7.58),(96.58±6.84),(130.29±5.21),(89.67±4.95)mm Hg](P<0.05).Three days before treatment,there was no significant difference in sleep quality and pain score between the observation group and the control group(P>0.05),3 days after treatment,the sleep quality(5.28±1.01)and pain score(2.67±0.14)of the observation group were lower than those of the control group[(12.65±3.27),(4.24±0.95)](P<0.05).Three days before treatment,there was no difference in fasting blood glucose,glycosylated hemoglobin,urine protein and other indicators between the observation group and the control group(P>0.05),3 days after treatment,fasting blood glucose(4.26±1.14)mmol/L,glycosylated hemoglobin(6.01±0.67)%,and urine protein(51.64±12.09)mg/L in the observation group were lower than those in the control group[(5.97±1.58)nmol/L,(6.68±0.41)%,(86.57±13.95)mg/L],with statistical significance(P<0.05).The scores of family relationship(79.58±5.24),physiological interval(76.59±5.26),mental health(82.67±5.41),physical pain(86.57±4.28),and social relationship(88.57±6.34)in the observation group were higher than those in the control group[(63.29±3.16),(56.24±2.15),(69.52±4.20),(64.28±3.04),(70.05±3.04)],with statistical significance(P<0.05).The adverse reactions in the observation group were 5.41%lower than those in the control group(25.00%),with a statistically significant difference(P<0.05).Conclusion For the elderly patients with hypertension,the combination of amlodipine and enalapril can effectively improve their blood pressure level,adjust their sleep quality,reduce their pain due to disease,ensure the stability of their blood glucose level,and further improve their quality of life.