达芬奇机器人辅助腹腔镜宫颈癌根治术对宫颈癌患者术后恢复效果及机体应激反应的影响

Da Vinci Robot-assisted Laparoscopic Radical Cervical Cancer Recovery in Cervical Cancer Patients Effect and The Influence of the Body Stress Response

目的探讨在宫颈癌治疗中应用达芬奇机器人辅助腹腔镜宫颈癌根治术(LRH)的效果。方法纳入82例宫颈癌患者,采用随机数字表法分为2组,各41例。对照组行LRH治疗,观察组行达芬奇机器人辅助LRH治疗。对2组手术相关指标、术后恢复效果、机体应激反应[肿瘤坏死因子α(TNF-α)、白介素-8(IL-8)和C反应蛋白(CRP)]、并发症进行比较。结果观察组术中出血量[(48.25±6.07)ml]、手术时间[(141.01±23.41)min]、术中补液量[(1879.63±432.45)ml]低于对照组[(62.18±7.16)ml、(151.97±22.36)min、(2106.48±500.49)ml],淋巴结清扫数[(28.41±3.29)个]高于对照组[(25.47±3.12)个],留置尿管时间[(12.39±2.31)d]、首次肛门排气时间[(1.82±0.40)d]、住院时间[(8.52±1.11)d]短于对照组[(13.86±2.46)d、(2.16±0.34)d、(11.39±1.31)d],IL-8[(13.51±1.52)ng/L]、CRP[(15.34±3.06)ng/L]、TNF-α[(18.06±3.12)pg/L]低于对照组[(18.42±3.18)ng/L、(19.16±2.10)ng/L、(22.34±4.19)pg/L],差异均有统计学意义(P<0.05)。2组并发症发生率比较,差异无统计学意义(P>0.05)。结论在宫颈癌治疗中应用达芬奇机器人辅助LRH可提高淋巴结清扫效果,缩短手术时间,减少出血量,且对机体造成的创伤较小,利于患者术后恢复,具有广阔的应用前景。

Objective To investigate the effect of Da Vinci robot-assisted laparoscopic radical cervical cancer resection(LRH)for patients with cervical cancer.Methods 82 cervical cancer patients were divided into 2 groups and 41 cases in each by randomized digital table.The control group was treated with LRH,and the observation group was treated with Da Vinci robot-assisted LRH treatment.Comparison of the 2 groups of surgery-related indicators,postoperative recovery effect,body stress response[tumor necrosis factor(TNF-α),interleukin-8(IL-8)and C response protein(CRP)],and complications.Results The intraoperative bleeding[(48.25±6.07)ml],operation time[(141.01±23.41)min],intraoperative rehydration[(1879.63±432.45)ml]was below the control group[(62.18±7.16)ml,(151.97±22.36)min,(2106.48±500.49)ml],The number of lymph node dissection[(28.41±3.29)]was higher than that in the control group[(25.47±3.12)],Liwelling catheter time[(12.39±2.31)d],first anal exhaust time[(1.82±0.40)d],hospital time[(8.52±1.11)d]shorter than control[(13.86±2.46)d,(2.16±0.34)d,(11.39±1.31)d],IL-8[(13.51±1.52)ng/L],CRP[(15.34±3.06)ng/L],TNF-[(18.06±3.12)pg/L]were below controls[(18.42±3.18)ng/L,(19.16±2.10)ng/L,(22.34±4.19)pg/L],The difference was statistical significant(P<0.05);Comparison of complication rates between the 2 groups had no statistically significant difference(P>0.05).Conclusion Da Vinci robot-assisted LRH treatment in cervical cancer patients can improve the effect of lymph node dissection,shorten the surgical time,reduce the bleeding volume,and cause less trauma to the body,and is conducive to the postoperative recovery of patients,and has broad application prospects.