非肌层浸润性膀胱癌患者术后复发的高危因素研究

Study on Risk Factors for Postoperative Recurrence in Patients with Non-mycular Invasive Bladder Cancer

目的分析影响非肌层浸润性膀胱癌(NMIBC)患者经尿道膀胱肿瘤电切术(TURBT)后复发的因素。方法回顾性分析85例NMIBC患者的临床资料,所有患者均行TURBT并结合规律膀胱内灌注化学治疗。术后随访12个月,统计术后复发情况,按照是否复发分为复发组和未复发组。同时收集患者一般资料,单因素、多因素Logistic分析NMIBC患者TURBT后复发的因素。结果术后随访12个月,85例NMIBC患者中有12例复发,占比14.12%。2组性别、年龄、BMI、肿瘤直径、合并高血压、合并糖尿病、是否初发比较,差异无统计学意义(P>0.05);复发组肿瘤TNM分期T1、肿瘤数目多发、肿瘤低分化、肿瘤再发的比率高于未复发组,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,肿瘤TNM分期T1、肿瘤数目多发、肿瘤低分化、肿瘤再发是NMIBC患者TURBT后复发的独立危险因素。结论肿瘤TNM分期T1、肿瘤数目多发、肿瘤低分化、肿瘤再发是NMIBC患者TURBT后复发的独立危险因素。

Objective To analyze the factors influencing the relapse after transurethral bladder tumor electroresection(TURBT)in patients with non-myosphere invasive bladder carcinoma(NMIBC).Methods Clinical data of 85 NMIBC patients were retrospectively analyzed,all patients received TURBT combined with regular intrabladder perfusion chemotherapy.After operative follow-up for 12 months,postoperative recurrence was counted,and divided into relapse and unrelapse groups according to relapse or not.General data were also collected,and univariate,multivariate Logistic analyzed the factors of recurrence after TURBT in NMIBC patients.Results Postoperative follow-up for 12 months,12 out of the 85 NMIBC patients had relapsed,Accounting for 14.12%;Gender,age,BMI,tumor diameter,hypertension,diabetes,and initial comparison,there had no statistically significant difference(P>0.05);In the relapsed group,the rate of TNM stage,low differentiation,and tumor recurrence were higher than the unrelapsed group,the differences were statistically significant(P<0.05);Multivariate Logistic regression analysis revealed that,Multiple number of T1,tumors in tumor TNM stage,low tumor differentiation,and tumor recurrence were independent risk factors for relapse after TURBT in NMIBC patients.Conclusion Multiple TNM stage,low differentiation and tumor recurrence are independent risk factors for recurrence in NMIBC patients.