SUV39H1的生物学功能研究进展

Research progress on biological functions of SUV39H1

SUV39H1是第一个被发现的人类组蛋白赖氨酸甲基转移酶(HMT),能够特异性甲基化H3K9,参与异染色质的形成和基因的沉默,进而发挥表观遗传调控作用。近年研究发现,SUV39H1同时具有抑癌效应和致癌效应,在肿瘤发生发展的调控中发挥重要作用。此外,在诸多疾病过程中均发现SUV39H1的异常表达,表明其广泛参与各种病理生理过程。文章回顾了近年有关SUV39H1与各类疾病过程联系的研究,总结了SUV39H1在生长发育及疾病发生发展过程中的调控机制,为相关疾病的诊断及治疗提供新的思路。

SUV39H1 is the first human histone lysine methyltransferase(HMT)discovered,which can specifically methylate H3K9,participate in the formation of heterochromatin and gene silencing,and then play an epigenetic role in regulation.Recent studies have found that SUV39H1 has both anti-tumor and carcinogenic effects,and plays an important role in the regulation of tumor occurrence and development.In addition,abnormal expression of SUV39H1 was found in many disease processes,indicating that it is widely involved in various pathophysiological processes.This article reviews the research on the relationship between SUV39H1 and various disease processes in recent years,summarizes the regulation mechanism of SUV39H1 in the process of growth,development and disease occurrence and development,and provides new ideas for the diagnosis and treatment of related diseases.