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温州地区老年期痴呆患者的分型、特点及用药

Classification,characteristics and medication of senile dementia patients in Wenzhou
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摘要 目的调查温州地区老年期痴呆患者的用药现状,为有效开展该类人群的药学监护和临床用药提供参考依据。方法回顾性分析2020年1月至12月温州地区3家市级医院的住院老年期痴呆患者202例,包括117例阿尔茨海默病(Alzheimer’s disease,AD)、56例血管性痴呆(vascular dementia,VD)与29例帕金森病痴呆(Pkinson’s disease dementia,PDD)患者,通过查阅病历的方式收集患者的基本信息、用药品种、使用频率,并对其进行统计分析,观察老年期痴呆患者药学监护的选择情况。结果3组患者性别、痴呆伴发精神行为障碍(behavioral and psychological symptoms of dementia,BPSD)、合并高脂血症与冠心病的一般资料比较,差异无统计学意义(P>0.05);3组患者的年龄、合并高血压与糖尿病的一般资料比较,差异有统计学意义(P<0.05)。AD患者使用胆碱酯酶抑制剂、N-甲基门冬氨酸受体拮抗剂、5-羟色胺再摄取抑制剂类(selective serotonin reuptake inhibitor,SSRI)抗抑郁药物、5-羟色胺和去甲肾上腺素再摄取抑制剂(serotonin noradrenergic reuptake inhibitor,SNaRI)类抗抑郁药物、去甲肾上腺素及特异性5-羟色胺受体拮抗剂类(noradrenergic and specific serotonergic antidepressants,NaSSAs)抗抑郁药物的使用率高于VD、PDD患者;VD患者使用营养脑神经药物的使用率高于AD、PDD患者;PDD患者使用抗精神分裂症药物的使用率高于AD、VD患者。119例老年期痴呆患者联合使用3~4种药物,50例患者联合使用超过5种药物,33例患者联合使用1~2种药物。结论不同类型的痴呆患者药物使用情况不一,药学监护能够有效改善老年期痴呆患者症状,临床需依据患者实际情况进行针对性的药学监护。 Objective To investigate the drug use status of senile dementia patients in Wenzhou,so as to provide a reference basis for effectively carrying out pharmaceutical care and clinical drug use in this group of people.Methods From January to December 2020,202 inpatients with senile dementia in three municipal hospitals in Wenzhou were selected,including 117 cases of Alzheimer's disease(AD),56 cases of vascular dementia(VD)and 29 cases of Parkinson's disease dementia(PDD).The basic information,drug varieties and frequency of use of the patients were collected by consulting the medical records,and statistically analyzed,to observe the selection of pharmaceutical care for senile dementia patients.Results There was no significant difference among the three groups in gender,dementia with behavioral and psychological symptoms of dementia(BPSD),hyperlipidemia and coronary heart disease(P>0.05);there were significant differences in age,hypertension and diabetes among the three groups(P<0.05).The use rate of cholinesterase inhibitors,N-methyl aspartate receptor antagonists,selective serotonin reuptake inhibitior(SSRI)antidepressants,serotonin noradrenergic reuptake inhibitor(SNaRI),antidepressants and noradrenergic and specific serotonergic antidepressants(NaSSAs)antidepressants in AD patients were higher than those in VD and PDD patients. The use rate of nutritional neuroleptics in VD patients was higher than that in AD and PDD patients;The use rate of antipsychotic drugs in PDD patients was higher than that in AD and VD patients. 119 patients with senile dementia were treated with 3-4 drugs, 50 patients with more than 5 drugs, and 33 patients with 1-2 drugs. Conclusion Different types of dementia patients have different drug use conditions. Pharmaceutical care can effectively improve the symptoms of senile dementia patients. Clinically, it is necessary to carry out targeted pharmaceutical care according to the actual situation of the patients.
作者 陈晔 宋秀娟 谢静静 黄曦 毛侠枫 CHEN Ye;SONG Xiujuan;XIE Jingjing;HUANG Xi;MAO Xiafeng(Department of Pharmacy,Wenzhou Seventh People's Hospital,Zhejiang,Wenzhou 325000,China;Department of Geriatric Somatic Diseases,Wenzhou Seventh People's Hospital,Zhejiang,Wenzhou 325000,China;Department of Pharmacy,Wenzhou Hospital of traditional Chinese Medicine,Zhejiang,Wenzhou 325000,China;Department of Pharmacy,Kangning Hospital Affiliated to Wenzhou Medical University,Zhejiang,Wenzhou 325007,China)
出处 《中国现代医生》 2022年第32期51-54,64,共5页 China Modern Doctor
基金 温州市基础性医疗卫生科技项目(Y2020846)。
关键词 温州地区 老年期痴呆 分型 药学监护 用药 Wenzhou Senile dementia Classification Pharmaceutical care Medication
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