内蒙古中部高原地区高尿酸血症患病情况及危险因素探讨

Prevalence and risk factors of hyperuricemia in the central plateau ofInner Mongolia

目的分析内蒙古中部高原地区高尿酸血症(hyperuricemia,HUA)患病情况及危险因素。方法选取2019至2021年锡林郭勒盟蒙医医院25609例体检人群为研究对象,根据是否患有高尿酸血症分为正常组和高尿酸组,分析各组不同性别、不同年龄HUA的患病情况,并探讨部分指标与高尿酸血症的相关性。结果共纳入20845例研究对象,其中男11984人(57.5%),血尿酸水平(375±86)μmol/L;女8861人(42.5%),血尿酸水平(261±69)μmol/L;纳入人群的总体血尿酸水平为(326±97)μmol/L。正常组及HUA组男性血尿酸水平均明显高于女性(P<0.001),男性随着年龄的增长平均血尿酸水平有下降趋势,女性50岁之前随着年龄增长平均血尿酸水平变化不大,50岁之后平均血尿酸水平有所升高。HUA组4292例,总体患病率20.6%。<30岁组1038例,30~39岁组1345例,40~49岁组871例,50~59岁组754例,≥60岁组284例;30~39岁组患病率最高,<30岁组次之,≥60岁组患病率显著降低。男性患者血尿酸水平在<30岁年龄组中最高。女性患者50岁以后血尿酸水平逐渐升高,血尿酸水平≥60岁年龄组中最高。近3年<30岁组、30~39岁组男性患者及40~49岁组女性患者血尿酸水平整体呈现逐年升高态势。Logistic回归分析显示年龄、性别、谷丙氨酸氨基转移酶(alanine aminotransferase,ALT)、三酰甘油(triglycerides,TG)、胆固醇(cholesterol,CHO)、尿素(urea nitrogen,UREA)、肌酐(creatinine,CREA)是HUA的危险因素。结论内蒙古中部高原地区男女血尿酸水平差异明显,男性血尿酸水平明显高于女性。年轻男性HUA患者血尿酸水平逐年升高,有年轻化趋势。年龄、性别、ALT、CHO、TG、UREA、CREA是HUA的危险因素。

Objective To analyze the risk factors of hyperuricemia(HUA)in the central plateau of Inner Mongolia.Methods A total of 25609 health examination population of Xilingol League Mongolian Medical Hospital from 2019 to 2021 as the research object,and were divided them into normal group and hyperuric acid group according to whether they had hyperuricemia.the prevalence of HUA in each group by sex and age were analyzed,the correlation between some indication and hyperuri cemia were explored.Results A total of 20845 subjects were included,11984 males(57.5%),the blood uric acid level of(375±86)μmol/L;8861 females(42.5%),the blood uric acid level of(261±69)μmol/L;The overall serum uric acid level was(326±97)μmol/L.The blood uric acid level of males in the normal group and HUA group was significantly higher than that of females(P<0.001).The blood uric acid level of males showed a downward trend with the increase of age,while the blood uric acid level of females showed a downward trend with the increase of age before the age of 50.However,after the age of 50,serum uric acid levels increased significantly.The HUA group included 4292 cases,with an overall prevalence of 20.6%.There were 1038 cases in the<30-year-old group,1345 in the 30-39-year-old group,871 in the 40-49-year-old group,754 in the 50-59-year-old group,and 284 in the≥60-year-old group;the 30-39-year-old group had the highest prevalence,<30-year-old group the age group followed,and the≥60-year-old group had a significantly lower prevalence.Serum uric acid levels in male patients were the highest in the<30-year-old age group.The serum uric acid level of female patients gradually increased after the age of 50,and the serum uric acid level was the highest in the≥60-year-old age group.In the past three years,the serum uric acid levels in the<30-year-old group,the male patients in the 30-39-year-old group,and the female patients in the 40-49-year-old group showed a trend of increasing year by year.Logistic regression analysis showed that age,gender,ALT,CHO,TG,UREA and CREA were risk factors for HUA.Conclusion In the central plateau of Inner Mongolia,there is a significant difference in blood uric acid levels between men and women,and the blood uric acid level in men is significantly higher than that in women.The serum uric acid level of young male HUA patients increases year by year,showing a younger trend.Age,gender,ALT,CHO,TG,UREA,CREA were risk factors for HUA.