利那洛肽联合复方聚乙二醇电解质散在门诊患者肠道准备中的临床应用

Clinical application of linaclotide combined with compound polyethylene glycol electrolytes powder in intestinal preparation of outpatients

目的 探讨利那洛肽联合复方聚乙二醇电解质散(polyethylene glycol electrolytes powder,PEG)用于门诊患者肠镜检查前肠道准备的安全性及有效性。方法 选取2020年8月至2021年8月于台州市中心医院(台州学院附属医院)行肠镜检查的150例患者为研究对象,按照不同的肠道准备方法将其分为3LPEG组(50例)、4L PEG组(50例)和3L PEG+利那洛肽组(50例)。通过Boston肠道准备评分量表(Boston bowel preparation scale,BBPS)评价三组患者的肠道准备效果,并比较三组患者的不良反应及对肠道准备方案的满意度。结果 3L PEG组患者的左半结肠、横结肠、右半结肠评分及BBPS总评分均显著低于4L PEG组和3L PEG+利那洛肽组(P<0.05);4L PEG组患者的左半结肠、横结肠、右半结肠评分及BBPS总评分与3L PEG+利那洛肽组比较,差异均无统计学意义(P>0.05)。3LPEG+利那洛肽组患者的首次排便时间明显短于3LPEG组和4LPEG组(F=18.860,P<0.001)。4L PEG组患者的满意度低于3L PEG组和3L PEG+利那洛肽组(P<0.05),3L PEG+利那洛肽组患者的满意度最高。4L PEG组患者的不良反应发生率显著高于3L PEG组和3L PEG+利那洛肽组(P<0.05)。结论 肠镜检查前使用利那洛肽联合PEG进行肠道准备,可提高患者肠道准备质量,降低服药中的不良反应,缩短首次排便时间,提高患者的满意度,值得临床推广应用。

Objective To investigate the safety and efficacy of linaclotide combined with polyethylene glycol electrolytes powder(PEG) for intestinal preparation before colonoscopy in outpatients. Methods From August 2020 to August 2021, 150 patients who underwent colonoscopy in Taizhou Central Hospital(Taizhou University Hospital)were divided into 3L PEG group(50 cases), 4L PEG group(50 cases) and 3L PEG + linaclotide group(50 cases)according to different intestinal preparation methods. The effect of bowel preparation was evaluated by Boston bowel preparation scale(BBPS), and the adverse reactions and satisfaction with bowel preparation were compared among the three groups. Results The scores of left colon, transverse colon, right colon and BBPS in 3L PEG group were significantly lower than those in 4L PEG group and 3L PEG + linaclotide group(P<0.05). The scores of left colon,transverse colon, right colon and BBPS in 4L PEG group were not significantly different from those in 3L PEG +linaclotide group(P>0.05). The first defecation time of 3L PEG + linaclotide group was significantly shorter than that of 3L PEG group and 4L PEG group(F=18.860, P<0.001). The satisfaction of 4L PEG group was lower than that of 3L PEG group and 3L PEG + linaclotide group(P<0.05). The satisfaction of 3L PEG + linaclotide group was the highest. The incidence of adverse reactions in 4L PEG group was significantly higher than that in 3L PEG group and 3L PEG + linaclotide group(P<0.05). Conclusion Linaclotide combined with PEG for intestinal preparation before colonoscopy can improve the quality of intestinal preparation, reduce the adverse reactions in taking medicine,shorten the time of first defecation and improve the satisfaction of patients, which is worthy of clinical application.