肝切除术中Pringle法肝门阻断时间对患者预后的影响

Effect of Pringle hilar occlusion time on prognosis of patients undergoing hepatectomy

目的:研究肝切除术中Pringle法肝门血流阻断时间对于患者预后的影响。方法:选择2019年1月至2021年1月就诊于中国人民解放军空军军医大学第一附属医院肝胆外科并行肝部分切除术的100例肝癌患者,根据术中Pringle法阻断肝门血流总时长分为阻断时间≤30 min组(50例)和阻断时间>30 min组(50例),比较两组患者的术中出血量、术后第1、3、5天ALT、AST、TBil的水平及总体腹水量,评估术中Pringle法肝门血流阻断时间对肝癌患者术后肝功能的影响。结果:术中使用Pringle法肝门血流阻断总时长≤30 min患者在术后ALT水平(术后第1、3天)、AST水平(术后第1天)、TBil水平(术后第3天)、腹水总量方面均低于术中肝门血流阻断总时长>30 min患者(P<0.05)。结论:术中Pringle法肝门血流阻断总时长对患者术后肝功能具有一定的影响。

Objective:To investigate the effect of Pringle’s hilar blood flow occlusion time on the prognosis of patients undergoing hepatectomy.Methods:A total of 100 patients with liver cancer who underwent partial hepatectomy in the Department of Hepatobiliary Surgery,the First Affiliated Hospital of PLA Air Force Medical University from January 2019 to January 2021 were selected.According to the total duration of intraoperative Pringle method to block hilar blood flow,they were divided into the blocking time≤30 min group(50 cases)and the blocking time>30 min group(50 cases).The intraoperative blood loss,the levels of ALT,AST,TBil and total ascites on the 1st,3rd,5th day after operation were compared between the two groups,and the effect of intraoperative Pringle method hilar blood flow blocking time on postoperative liver function of patients with liver cancer was evaluated.Results:The levels of ALT(1 and 3 days after operation),AST(1 day after operation),TBil(3 days after operation),and total ascites in patients with total duration of hilar blood flow occlusion≤30 minutes using Pringle method were lower than those in patients with total duration of hilar blood flow occlusion>30 minutes(P<0.05).Conclusion:The total duration of hilar blood flow occlusion by Pringle method has a certain effe ct on postoperative liver function.