补阳还五汤加味对后循环缺血性孤立性眩晕老年患者脑血流及血管内皮功能的影响

Effects of Modified Buyang Huanwu Decoction on Cerebral Blood Flow and Vascular Endothelial Function in Elderly Patients with Posterior Circulation Ischemic Isolated Vertigo

目的探讨与分析补阳还五汤加味对后循环缺血性孤立性眩晕老年患者脑血流及血管内皮功能的影响。方法选择2020年2月~2022年2月在江苏省徐州市中医院诊治的后循环缺血性孤立性眩晕老年患者70例作为研究对象,根据信封抽签1∶1原则把患者随机分为中医组与对照组,各35例。对照组给予常规西药治疗,中医组在对照组治疗的基础上给予补阳还五汤加味治疗,两组都治疗观察4周,观察两组患者的疗效,对比两组患者的神经功能和日常生活能力、脑血流(全血黏度、纤维蛋白原)及血清神经肽Y(Neuropeptide Y,NPY)变化情况。结果中医组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组美国国立卫生研究所脑卒中评分(National Institutes of Health Stroke Scale,NIHSS)明显低于治疗前,日常生活活动能力量表(Activity of Daily Living Scale,ADL)评分明显高于治疗前,差异有统计学意义(P<0.05),中医组NIHSS评分低于对照组,ADL评分高于对照组,差异有统计学意义(P<0.05)。治疗后,两组全血黏度、纤维蛋白原均显著低于治疗前,中医组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组NPY含量明显高于治疗前,且中医组高于对照组,差异有统计学意义(P<0.05)。结论补阳还五汤加味在后循环缺血性孤立性眩晕老年患者中的应用能促进改善脑血流状况,也可提高患者的血管内皮功能,提高患者的治疗效果,改善神经缺损状况,提高患者的日常生活能力。

Objective To explore and analysis the effects of Modified Buyang Huanwu Tang on cerebral blood flow and vascular endothelial function in elderly patients with posterior circulation ischemic isolated vertigo.Methods From February 2020 to February 2022,70 elderly patients with posterior circulation ischemic isolated vertigo who were diagnosed and treated in Xuzhou Hospital of Traditional Chinese Medicine,Jiangsu Province,were selected as the research subjects,and the patients were divided into the traditional Chinese medicine group and the control group according to the principle of 1:1 by drawing lots on envelopes,with 35 cases in each group.The control group was given conventional western medicine,and the traditional Chinese medicine group was given Modified Buyang Huanwu Tang on the basis of the control group.Observe the curative eff ect of the two groups of patients,and compare the neurological function,daily living ability,cerebral blood flow(whole blood viscosity,fi brinogen)and serum neuropeptide Y(NPY)before and after treatment.Results The total effective rates of the traditional Chinese medicine group were significantly higher than the control group(P<0.05).After treatment,the NIHSS scores of the two groups were significantly lower than those before treatment(P<0.05),and the ADL scores were significantly higher than those before treatment(P<0.05),the NIHSS scores of the traditional Chinese medicine group were significantly lower than that in the control group,and the ADL scores were significantly higher than that in the control group.After treatment,the whole blood viscosity and fibrinogen in the two groups were significantly lower than those before treatment(P<0.05),and the traditional Chinese medicine group was also significantly lower than the control group(P<0.05).The NPY content of the two groups after treatment were significantly higher than that before treatment(P<0.05),and the traditional Chinese medicine group was also significantly higher than the control group after treatment(P<0.05).Conclusion The application of Modifi ed Buyang Huanwu Tang in elderly patients with posterior circulation ischemic isolated vertigo can promote the improvement of cerebral blood flow,and can also improve the vascular endothelial function of patients,improve the therapeutic eff ect of patients,improve the state of nerve defects,and improve the quality of life,it can improve the patient’s ability of daily living.