光流控光镊操控研究进展

Research progress on optofluidic optical tweezers

光镊技术利用光与颗粒之间动量传递的力学效应对颗粒进行操控,具有无接触、操控尺寸小等优点,在生物医学和物理化学等领域具有重要的应用价值。光镊操控起初主要是在静态环境中对单个和多个颗粒进行操控,分为单/多光束光镊、全息光镊、等离子光镊、光纤光镊、特殊光力/力矩光镊和光电热镊子等。光镊技术随后与微流控技术进行结合诞生了光流控光镊操控技术,大大提高了可操控颗粒的数量和效率,同时也丰富了操控功能。本文从光流控光镊类别、物理机制以及生物医学应用等方面出发,对光流控光镊操控进行了回顾和讨论,最后对光流控光镊操控潜在的挑战进行了总结,对未来的发展方向如高通量单病毒操控和检测、光驱动机器人等进行了展望。

Optical tweezers,which utilize optical forces from the momenta exchange of light and a particle,have advantages of being non-invasive and has a small manipulating size. Therefore,they have important applications in the biomedical,physical,and chemical sciences. Optical tweezers at the early stage manipulate single or multiple particles in a motionless environment and can be classified into various classical categories,such as single/multiple-beam optical tweezers,holographic optical tweezers,plasmon optical tweezers,fiber optical tweezers,optical tweezers with special forces and torques,opto-thermal-electrical tweezers,etc. Optical tweezers later fuse with the optofluidic technique,increasing manipulating quantity and efficiency. This study reviews and comments on the recent progresses of optofluidic manipulation by focusing on the categories of optofluidic optical tweezers,mechanisms of optical tweezers as well as their biomedical applications. Meanwhile,potential challenges of optofluidic manipulation are summarized. In addition,perspectives on the future developments of optofluidic optical tweezers such as highthroughput manipulation and detection of single viruses as well as light-driven microrobots are provided.