中药经皮给药制剂的分子药剂学研究进展

Advances in Molecular Pharmaceutics of Transdermal Drug Delivery Preparations of Traditional Chinese Medicine

分子药剂学是从分子水平研究制剂作用规律与机理的学科,它可阐明经皮给药制剂的成型原理以及药物、基质、生物机体三者之间的分子间相互作用影响制剂释药、经皮渗透行为的分子机制。近年来,分子药剂学在经皮给药制剂中得到越来越多的应用。通过对分子药剂学在中药经皮给药制剂中的应用进行文献综述,可以探讨中药经皮给药制剂在制剂成型、释药和渗透的分子间相互作用,以及阐明中药经皮渗透促进剂促进药物渗透皮肤的分子机制,为分子药剂学在中药经皮给药制剂中的应用提供参考,从而推动中药经皮给药制剂的开发和应用。

Molecular pharmaceutics is a discipline that studies the law and mechanism of preparations at the molecular level.It can clarify the forming principle of transdermal drug delivery and the molecular mechanism of drug release and transdermal penetration affected by the molecular interaction among drugs,matrices and organisms.In recent years,molecular pharmaceutics has been applied more and more in transdermal drug delivery.In this paper,the application of molecular pharmaceutics in transdermal drug delivery preparations of traditional Chinese medicine was reviewed,and the molecular interaction of transdermal drug delivery in preparation,drug release and skin penetration,as well as the molecular mechanism of penetration enhancer in traditional Chinese medicine promoting drug penetration into skin was investigated.It provides reference for the application of molecular pharmaceutics in the study of transdermal drug delivery preparations,so as to promote the development and wide application of transdermal drug delivery preparations of traditional Chinese medicine.