摘要
Circular RNAs(circRNAs)are a class of single‐stranded closed RNAs that are produced by the back splicing of precursor mRNAs.The formation of circRNAs mainly involves intron‐pairing‐driven circularization,RNA‐binding protein(RBP)‐driven circularization,and lariat‐driven circularization.The vast majority of circRNAs are found in the cytoplasm,and some intron‐containing circRNAs are localized in the nucleus.CircRNAs have been found to function as microRNA(miRNA)sponges,interact with RBPs and translate proteins,and play an important regulatory role in the development and progression of cancer.CircRNAs exhibit tissue‐and developmental stage–specific expression and are stable,with longer half‐lives than linear RNAs.CircRNAs have great potential as biomarkers for cancer diagnosis and prognosis,which is highlighted by their detectability in tissues,especially in fluid biopsy samples such as plasma,saliva,and urine.Here,we review the current studies on the properties and functions of circRNAs and their clinical application value.
基金
Fundamental Research Funds for the Central Universities,Grant/Award Number:3332020023
Beijing Hope Run Special Fund of Cancer Foundation of China,Grant/Award Number:LC2019A04
National High Level Hospital Clinical Research Funding,Grant/Award Number:BJ-2022-194
National Natural Science Foundation of China,Grant/Award Number:81871107。
