Diagnostic value of genetic mutation analysis and mutation profiling of cell-free DNA in intraocular fluid for vitreoretinal lymphoma

Dear editor,Vitreoretinal lymphoma(VRL)is a rare intraocular malignant lymphoma affecting the vitreous and/or retina.Pathological diagnosis is challenging.Retinal biopsies have high risks of irreversible visual impairment(even blind-ness),which are not used in clinics for patients with residual visual function.The limited cellular yield from vit-reous biopsies and the cell lysis also contribute to the low detection rates of VRL using cytopathology[1].