氢溴酸西酞普兰片治疗脑卒中后焦虑抑郁伴失眠患者的效果及对睡眠质量的影响

Effect of Citalopram Hydrobromide Tablets in the Treatment of Post-stroke Anxiety and Depression with Insomnia and Its Impact on Sleep Quality

目的:探讨氢溴酸西酞普兰片治疗脑卒中后焦虑抑郁伴失眠患者的效果及对睡眠质量的影响。方法:选取2021年2月至2022年1月南安市医院收治脑卒中合并焦虑抑郁伴失眠的患者84例作为研究对象,随机分为对照组和观察组,每组42例。对照组采用帕罗西汀治疗,观察组采用氢溴酸西酞普兰治疗。比较2组患者负性情绪、睡眠质量、神经功能、自主生活能力、不良反应。结果:治疗前,2组患者焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分比较,差异均无统计学意义(均P>0.05);治疗后,观察组患者SAS评分及SDS评分均低于对照组,2组比较差异均有统计学意义(均P<0.05)。治疗前,2组患者匹兹堡睡眠质量量表评分(PSQI)、睡眠时间比较,差异均无统计学意义(均P>0.05);治疗后,观察组患者PSQI评分低于对照组,睡眠时间长于对照组,2组比较差异均有统计学意义(均P<0.05)。治疗前,2组患者美国国立卫生院卒中量表(NIHSS)评分及自主生活能力(ADL)评分比较,差异均无统计学意义(均P>0.05);治疗后,2组患者NIHSS评分比较,差异无统计学意义(均P>0.05);观察组ADL低于对照组,2组比较差异有统计学意义(P<0.05)。观察组不良反应发生率为7.14%,对照组不良反应发生率为14.29%,2组比较差异无统计学意义(P>0.05)。结论:氢溴酸西酞普兰治疗卒中后焦虑抑郁伴睡眠障碍具有较好疗效,可较好改善患者不良情绪,提高其睡眠质量;氢溴酸西酞普兰改善患者神经功能与帕罗西汀治疗效果相同,可提高其自主生活能力;服用氢溴酸西酞普兰未见严重不良反应发生。

Objective:To explore the effect of citalopram hydrobromide tablets in the treatment of post-stroke anxiety and depression with insomnia and its impact on sleep quality.Methods:From February 2021 to January 2022,84 patients with stroke were selected as the research object.The patients had anxiety,depression and insomnia after stroke.The patients were randomly divided into two groups with 42 cases in each group by computer statistical software.The control group was treated with paroxetine,and the observation group was treated with citalopram hydrobromide.The negative emotions,sleep quality,neurological function,autonomous living ability and adverse reactions were compared between the two groups.Results:There was no significant difference in SAS and SDS between the two groups before treatment(P>0.05);After treatment,the SAS and SDS scores of the observation group were lower than those of the control group(P<0.05).Before treatment,there was no significant difference in Pittsburgh Sleep Quality Scale score(PSQI) and sleep time between the two groups(P>0.05);After treatment,the PSQI score of the observation group was lower than that of the control group,and the sleep time was longer than that of the control group(P<0.05).There was no significant difference in NIHSS and ADL scores between the two groups before treatment(P>0.05);There was no significant difference in NIHSS between the two groups(P>0.05),and the ADL of the observation group was lower than that of the control group(P<0.05).The incidence of adverse reactions was 7.14%(3/42) in the observation group and 14.29%(6/42) in the control group.There was no significant difference between the two groups(P>0.05).Conclusion:Citalopram hydrobromide has a good effect in the treatment of post-stroke anxiety and depression with sleep disorders,which can promote the improvement of patients’ mental mood and improve the quality of sleep;At the same time,citalopram has no negative effect on patients’ neurological function,and can also promote the improvement of patients’ autonomous living ability;In addition,no serious adverse reactions were found after taking citalopram.