摘要
Background:Mushrooms include a wide variety of bioactive compounds that have been linked to therapeutic and nutritional benefits,making them a potential source of new medications and functional foods.Objective:The goal of this study is to offer a complete overview of the mushroom’s modulatory effects on inflam-matory signaling pathways,which leads to the inhibition of inflammation in various types of immune cells and animal models.Methods:This study reviewed the inhibitory effects of mushrooms on the inflammation process through the modulation of the pro-inflammatory mediators and associated signaling pathways.A literature search in PubMed and Google Scholar was conducted for the relevant original research and review articles on the anti-inflammatory effects of mushrooms.Related articles published in English were selected,studied and discussed.Results:As revealed by the selected articles,bioactive molecules which include peptides,polysaccharides,ter-penes,sterols,fatty acids,and phenols have been extracted from the powder,concentrate,and different solvent extracts of edible mushrooms.These bioactive molecules have shown significant efficacy in inhibiting the major pro-inflammatory biomarkers and associated pathways in in vivo and in vitro settings.Conclusion:This review demonstrated that mushrooms significantly inhibit the production of pro-inflammatory mediators and can be developed for clinical use as anti-inflammatory agents.Further research is required to establish the comparative efficacy between mushrooms and NSAID especially in the in vivo inhibitory activity against the production of cyclooxygenase and pro-inflammatory cytokines.
