内质网驻留蛋白UNC93B1及TLR7在系统性红斑狼疮发病中的作用及治疗进展

Update of endoplasmic reticulum resident protein UNC93B1 and TLR7 in systemic lupus erythematosus

多通道跨膜蛋白UNC93B1是一种内质网驻留蛋白,能将TLR3、TLR7、TLR8、TLR9和TLR13从内质网运输到它们的最终细胞位置,它们识别核酸并定位于内体。UNC93B1中的错义突变破坏了内体中TLR水平的平衡,可导致自身免疫。系统性红斑狼疮是一种自身免疫性疾病,可以影响皮肤、心脏及肾脏等多脏器,导致严重的器官并发症甚至死亡。本文对胞内UNC93B1与TLR7在系统性红斑狼疮中作用及相关治疗进行综述,可能为SLE及其它自身免疫性疾病提供新的治疗途径。

The multi-channel transmembrane protein UNC93 B1 is an endoplasmic reticulum resident protein that can transport TLR3,TLR7,TLR8,TLR9 and TLR13 from the endoplasmic reticulum to their final cellular location.They recognize nucleic acids and localize in endosomes.The missense mutation in UNC93 B1 disrupts the balance of TLR levels in the endosome and can lead to autoimmunity.Systemic lupus erythematosus is an autoimmune disease that can affect multiple organs such as the skin,heart,and kidneys,leading to serious organ complications and even death.This paper systematically reviews the role of intracellular UNC93 B1 and TLR7 in systemic lupus erythematosus,which may provide a new treatment approach for SLE and other autoimmune diseases.