中老年肌肉减少症与非酒精性脂肪性肝病的关系

Relationship between sarcopenia and non-alcoholic fatty liver disease in middle-aged and elderly patients

目的:探讨中老年肌肉减少症(SP)与非酒精性脂肪性肝病(NAFLD)的关系,为中老年SP的防治提供理论依据。方法:分析1363例中老年体检者的临床、实验室、肝脏超声、人体成分及骨骼肌功能测量相关资料。结果:本研究中SP患病率6.31%(86/1363),NAFLD 354例(23.97%),NAFLD组与正常组SP患病率存在显著差异(15.54%vs 2.82%,P<0.05)。年龄、2型糖尿病发病率、肌肉量、四肢肌肉量(ASM)、骨骼肌指数(SMI)、内脏脂肪面积、体脂肪量、腰臀比在两组间比较,差异均有统计学意义(P<0.05)。趋势χ^(2)检验结果显示SP患病率随年龄、NAFLD程度增加而升高(P<0.05)。结论:中老年人群SP患病率较高,SP患病率随着NAFLD程度增加而升高;应积极控制NAFLD以防治中老年SP的发生。

Objective:To explore the relationship between sarcopenia and nonalcoholic fatty liver disease(NAFLD)in middle-aged and elderly people,and to provide a theoretical basis for the prevention and treatment of sarcopenia in middle-aged and elderly people.Methods:The clinical,laboratory,liver ultrasound,human composition,and skeletal muscle function of 1363 participants who underwent annual physical examination were analyzed retrospectively.Results:In this study,the prevalence of SP was 6.31%(86/1363)and 354 cases of NAFLD(23.97%).There was a significant difference in the prevalence of SP between NAFLD group and the normal group(15.54%vs 2.82%,P<0.05).Age,type two diabetes incidence rate,muscle mass,muscle mass(ASM),skeletal muscle index(SMI),visceral fat area,body fat,and waist-hip ratio were significantly different between the two groups(P<0.05).trend Chi-Square test results showed that the prevalence of SP increased with age and the degree of NAFLD(all P<0.05).Conclusion:The prevalence of SP in middle-aged and elderly people is higher,and the prevalence of SP increases with the increase of NAFLD;NAFLD should be actively controlled to prevent the occurrence of SP in middle-aged and elderly people.