脂质体修饰性材料应用研究进展

Progress in Application of Liposomes Modified Materials

脂质体作为低毒性与免疫原性的药物载体已被应用于难溶性、不稳定、毒性等药物的递送,但传统脂质体仍存在稳定性差、体内循环时间不足、主动靶向性不明显等缺陷,因此选择适宜的修饰性材料制备脂质体已成为必要手段。修饰脂质体的方法主要有:在膜材中加入表面活性剂或改性物质,在膜表面嵌插靶向配体物质,将配体与膜材偶联共同组成脂质体结构。通过总结近年来脂质体常用的修饰性材料,阐释修饰原理并分析其优势及弊端,为脂质体的研究与开发提供借鉴。

As a drug carrier with low toxicity and immunogenicity,liposomes have been used in the delivery of insoluble,unstable and toxic drugs.However,traditional liposomes still have some defects,such as poor stability,insufficient circulation time in vivo,and unclear active targeting,therefore,it is necessary to select appropriate modified materials to prepare liposomes.The methods of modifying liposomes mainly include adding surfactants or modified substances to the membrane materials,inserting targeted ligands on the membrane surface,or coupling the ligand with the membrane materials to form the liposomes structure.This paper summarizes the commonly used modification materials of liposomes in recent years,explains the modification principle and analyzes its advantages and disadvantages,so as to provide reference for the research and development of liposomes.