低分子肝素联合阿司匹林治疗妊娠期高血压对氧化应激及子宫动脉血流的影响

Effects of low molecular weight heparin combined with aspirin on oxidative stress and uterine artery blood flow in patients with hypertensive disorder complicating pregnancy

目的探讨低分子肝素联合阿司匹林对妊娠期高血压患者氧化应激及子宫动脉血流的影响。方法选取本院收治的妊娠期高血压患者100例,随机数字表法分为对照组50例(低分子肝素)和研究组50例(低分子肝素联合阿司匹林),对比两组氧化应激指标、子宫动脉血流指标。结果与治疗前比较,治疗后两组血清脂质过氧化物(LPO)、同型半胱氨酸(Hcy)水平均降低,研究组低于对照组,血清谷胱甘肽过氧化物酶(GSH-PX)、超氧化物歧化酶(SOD)水平则升高,研究组高于对照组;与治疗前比较,治疗后两组搏动指数(PI)、阻力指数(RI)、脐动脉舒张压血流速度高低比例(S/D)均降低,研究组高于对照组,差异具有统计学意义(P<0.05)。结论低分子肝素联合阿司匹林治疗妊娠期高血压,有助于稳定子宫动脉血流指标,降低氧化应激水平。

Objective To investigate the effect of low molecular weight heparin combined with aspirin on oxidative stress and uterine artery blood flow in patients with hypertensive disorder complicating pregnancy.Methods A total of 100 patients with hypertensive disorder complicating pregnancy were selected and randomly divided into the control group(50 cases,low molecular weight heparin)and the research group(50 cases,low molecular weight heparin combined with aspirin)according to random number table.The oxidative stress indicators and uterine artery blood flow indicators of the two groups were compared.Results Compared with those before treatment,the serum lipid peroxide(LPO)and homocysteine(Hcy)levels in the two groups decreased after treatment,which were lower in the research group than in the control group,while the serum glutathione peroxidase(GSH-PX),superoxide dismutase(SOD)levels increased,which were higher in the research group than in the control group.Compared with those before treatment,the high pulsatility index(PI),resistance index(RI),umbilical artery diastolic blood flow velocity low ratio(S/D)were lower in the two groups after treatment,and those in the research group were higher than those in the control group,with statistically significant difference(P<0.05).Conclusion Low molecular weight heparin combined with aspirin in the treatment of hypertensive disorder complicating pregnancy helps to stabilize uterine artery blood flow indicators and reduce oxidative stress levels.