硝苯地平控释片辅助治疗妊娠期高血压疾病先兆子痫的临床效果

Clinical effect of adjuvant nifedipine controlled-release tablets in the treatment of pregnancy-induced hypertension and preeclampsia

目的分析妊娠期高血压疾病先兆子痫产妇治疗中联合运用拉贝洛尔、硝苯地平控释片、硫酸镁的临床效果。方法选取60例妊娠期高血压疾病先兆子痫产妇,以随机数字表法分为对照组(30例,拉贝洛尔+硫酸镁)和研究组(30例,对照组+硝苯地平控释片),均治疗7 d。比较两组治疗后临床效果,治疗前后血压及24 h尿蛋白水平,母婴预后结局。结果治疗后,研究组产妇临床总体有效率高于对照组;与治疗前比,治疗后两组产妇舒张压、收缩压及24 h尿蛋白水平均降低,且研究组低于对照组;研究组母婴不良结局总发生率低于对照组,差异有统计学意义(P<0.05)。结论妊娠期高血压疾病先兆子痫产妇采用硝苯地平控释片辅助治疗,可有效改善产妇血压和蛋白尿水平,提升临床治疗效果,改善母婴结局。

Objective To analyze the clinical effect of labetalol,nifedipine controlled-release tablets and magnesium sulfate in the treatment of preeclampsia gravida with pregnancy induced hypertension.Methods A total of 60 pregnant women with pregnancy-induced hypertension and preeclampsia were selected and divided into the control group(30 cases,labetalol+magnesium sulfate)and the study group(30 cases,the control group+nifedipine controlled-release tablets)by random number table method.Both group treated for 7 d.The clinical effects after treatment,blood pressure and 24 h urine protein levels before and after treatment,maternal and infant outcomes were compared between the two groups.Results After treatment,the overall clinical effective rate of puerperium in the study group was higher than that in the control group.Compared with before treatment,the diastolic blood pressure,systolic blood pressure and 24 h urine protein levels of the two groups of puerperae decreased after treatment,and the study group was lower than the control group.The overall incidence of maternal and infant adverse outcomes in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Preeclampsia of pregnancy induced hypertension nifedipine controlled-release tablets can effectively improve maternal blood pressure and proteinuria level,enhance clinical treatment effect,and improve maternal and infant outcomes.