卡前列素氨丁三醇在乙肝产妇剖宫产产后出血防治中的应用

Application of carboprost tromethamine in prevention and treatment of postpartum hemorrhage of hepatitis b parturients after cesarean section

目的探讨卡前列素氨丁三醇在乙肝产妇剖宫产产后出血防治中的应用。方法回顾性选取本院进行产检且行剖宫产术的40例乙肝产妇,按照所用药物的差异分为对照组(缩宫素)和研究组(缩宫素+卡前列素氨丁三醇),各20例。分析两组产后出血情况、相关临床指标,治疗前后血浆Ca^(2+)、D-二聚体(D-D)水平,并进行安全性分析。结果研究组产后2 h及24 h出血量均少于对照组,研究组产后出血发生率5.00%则低于对照组30.00%;研究组宫缩持续时间长于对照组,恶露持续时间及止血时间均短于对照组;与治疗前比,治疗后两组血浆Ca^(2+)水平均升高,研究组高于对照组,血浆D-D水平则降低,研究组低于对照组,差异具有统计学意义(P<0.05)。结论卡前列素氨丁三醇能降低乙肝产妇剖宫产产后出血的发生率,缩短其止血时间,并有效调控血浆Ca^(2+)、D-D水平,安全性好。

Objective To explore the application of carboprost tromethamine in the prevention and treatment of postpartum hemorrhage of hepatitis b parturients after cesarean section.Methods A total of 40 hepatitis b parturients who underwent antenatal examination and cesarean section in our hospital were selected retrospectively and divided into the control group(oxytocin)and the research group(oxytocin+carboprost tromethamine)according to the difference of the drugs used,20 cases each.The postpartum hemorrhage,related clinical indicators,plasma Ca^(2+),D-dimer(D-D)levels before and after treatment,and safety were analyzed in the two groups.Results The amount of postpartum hemorrhage in the research group was less than that in the control group at 2 h and 24 h postpartum,and the incidence rate of postpartum hemorrhage in the research group 5.00%was lower than 30.00%in the control group.The duration of uterine contraction in the research group was longer than that in the control group,and the duration of lochia and hemostatic time were shorter than those in the control group.Compared with those before treatment,plasma Ca^(2+)levels in the two groups increased after treatment,which was higher in the research group than in the control group,while plasma D-D levels decreased,which was lower in the research group than in the control group.The differences were statistically significant(P<0.05).Conclusion Carboprost tromethamine can reduce the amount of bleeding of hepatitis b parturients after cesarean section,shorten the time of hemostasis,and effectively regulate the plasma levels of Ca^(2+)and D-D with good safety.