血清VEGF、HE_(4)及CA125对卵巢癌诊断及预后评估的价值

Value of combined detection of serum VEGF,HE_(4) and CA125 in the diagnosis and prognosis of ovarian cancer

目的探讨血管内皮生长因子(VEGF)、人附睾蛋白4(HE_(4))及糖链抗原125(CA125)在卵巢癌诊断和预后评估中的价值。方法选取228例确诊且经手术治疗的卵巢肿瘤患者,测定术前及术后患者血清VEGF、HE_(4)及CA125水平,分析其对卵巢癌的诊断及评估价值。结果VEGF、HE_(4)及CA125水平在卵巢癌组明显高于良性肿瘤组,差异有统计学意义(P<0.05);在卵巢癌Ⅲ~Ⅳ期明显高于Ⅰ~Ⅱ期,差异有统计学意义(P<0.05);在上皮性卵巢癌(EOC)组中明显高于非上皮性卵巢癌(NEOC)组,差异有统计学意义(P<0.05);卵巢癌患者经过手术及术后化疗后,血清VEGF、HE_(4)及CA125水平明显低于治疗前,差异有统计学意义(P<0.05)。结论血清VEGF、HE_(4)及CA125水平与卵巢癌的发生、发展密切相关,对卵巢癌的早期诊断和预后评估具有重要意义。

Objective To investigate the value of vascular endothelial growth factor(VEGF),human epididymal protein 4(HE_(4))and glycan antigen 125(CA125)in the diagnosis and prognosis evaluation of ovarian cancer.Methods The serum levels of VEGF,HE_(4) and CA125 were measured before and after operation in 228 patients with ovarian cancer,and their value in the diagnosis and evaluation of ovarian cancer was analyzed.Results The levels of VEGF,HE_(4) and CA125 in ovarian cancer group were significantly higher than those in benign tumor group(P<0.05).It was significantly higher in stageⅢ~Ⅳthan in stageⅠ~Ⅱ(P<0.05).Epithelial ovarian cancer(EOC)group was significantly higher than non-epithelial ovarian cancer(NEOC)group,and the difference was statistically significant(P<0.05).After surgery and postoperative chemotherapy,the serum levels of VEGF,HE_(4) and CA125 in ovarian cancer patients were significantly lower than those before treatment,and the differences were statistically significant(P<0.05).Conclusion Serum VEGF,HE_(4) and CA125 levels are closely related to the occurrence and development of ovarian cancer,which is of great significance for the early diagnosis and prognosis evaluation of ovarian cancer.