探讨女性生殖道高危型HPV及沙眼衣原体感染与宫颈疾病的关系

To explore the relationship between High-risk HPV and Chlamydia trachomatis infection in female genital tract and cervical disease

目的探讨女性生殖道高危型人乳头瘤病毒(HPV)及沙眼衣原体感染与宫颈疾病之间的关系。方法选取500例宫颈疾病患者,其中慢性宫颈炎患者200例(慢性宫颈炎组),宫颈低级别鳞状上皮内病变(LSIL)患者160例(LSIL组),宫颈高级别鳞状上皮内病变(HSIL)及以上患者140例(HSIL及以上组)。统计四组高危型HPV及沙眼衣原体感染率,并行多因素Logistic回归分析。另选取同期500例作为对照组,行高危型HPV及沙眼衣原体筛查。结果慢性宫颈炎组、LSIL组、HSIL及以上组高危型HPV及沙眼衣原体感染率均高于对照组,且组间呈递增趋势,差异显著(P<0.05)。慢性宫颈炎组、LSIL组、HSIL及以上组沙眼衣原体阳性者中高危型HPV感染率均高于对照组,且组间呈递增趋势,差异显著(P<0.05)。经Logistic回归分析显示:高危型HPV及沙眼衣原体感染均是宫颈疾病的危险因素(P<0.05)。结论女性生殖道高危型HPV感染及沙眼衣原体感染均是导致宫颈疾病的危险因素,临床应尽早确诊并予以干预,以控制宫颈病变进展。

Objective To investigate the relationship between High risk human papillomavirus(HPV)and Chlamydia trachomatis infection in female genital tract and cervical diseases.Methods 500 patients with cervical diseases were selected,including 200 patients with chronic cervicitis(chronic cervicitis group),160 patients with low-grade squamous intraepithelial lesion(LSIL group),and 140 patients with high-grade squamous intraepithelial lesion(HSIL group)or above.The infection rates of highrisk HPV and Chlamydia trachomatis were analyzed by multivariate Logistic regression.At the same time,another 500 patients were selected as the control group and screened for high-risk HPV and Chlamydia trachomatis.Results The infection rates of high-risk HPV and chlamydia trachomatis in chronic cervicitis group,LSIL group,HSIL and above group were higher than those in control group,with a significant difference(P<0.05).The infection rate of medium-high risk HPV in Chlamydia trachomatis positive patients in chronic cervicitis group,LSIL group,HSIL and above group was higher than that in control group,with a significant difference(P<0.05).Logistic regression analysis showed that high-risk HPV and Chlamydia trachomatis infection were risk factors for cervical disease(P<0.05).Conclusion High-risk HPV infection in female genital tract and Chlamydia trachomatis infection are both risk factors for cervical disease,Clinical diagnosis and intervention should be made as soon as possible to control the progression of cervical lesions.