甲状腺功能系统性治疗妊娠合并甲亢症患者的临床效果分析

Effect analysis of systemic treatment of thyroid function in pregnancy combined with hyperthyroidism

目的 探讨甲状腺功能系统性治疗妊娠合并甲亢症患者的临床效果。方法 回顾性选取本院收治的60例妊娠合并甲亢症患者作为本研究的研究对象,按照治疗方法分为对照组29例(甲巯咪唑)和研究组31例(丙基硫氧嘧啶)。比较两组治疗前后甲状腺激素水平,妊娠合并症及新生儿健康状况。结果 与治疗前比较,治疗后,研究组血清游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))水平均降低,血清促甲状腺素(TSH)水平则升高,且与对照组比较,研究组血清FT_(3)、FT_(4)水平相对较低,血清TSH水平则相对较高;与对照组31.03%比,研究组妊娠合并症总发生率6.45%相对较低;与对照组24.14%比,研究组新生儿早产、畸形、甲低、窒息各项的总发生率6.45%相对较低,差异具有统计学意义(P<0.05)。结论 妊娠合并甲亢症患者在丙基硫氧嘧啶治疗下甲状腺功能可逐步好转,且还可降低患者妊娠期合并其他症状、新生儿异常情况的发生率。

Objective To explore the clinical effect of systemic treatment of thyroid function on pregnancy complicated with hyperthyroidism. Methods A total of 60 pregnancy patients with hyperthyroidism treated in our hospital were retrospectively selected as the research object. According to the treatment method, they were divided into the control group of 29 cases(methimazole)and the research group of 31 cases(propylthiouracil). The thyroid hormone levels before and after treatment, pregnancy complications and neonatal health status were compared between the two groups. Results Compared with those before treatment,after treatment, the serum free triiodothyronine(FT_(3)) and free thyroxine(FT_(4)) levels of the research group decreased, while the serum thyroid Stimulating Hormone(TSH) level increased. Compared with the control group, the serum FTand FTlevels of the research group relatively low, while the serum TSH level relatively high. Compared with 31.03% of the control group, the total incidence rate of pregnancy complications of 6.45% in the research group relatively low. The overall incidence of preterm birth, malformations,hypothyroidism, and asphyxia in the research group 6.45% was less than 24.14% in the control group and the difference was statistically significant(P<0.05). Conclusion Patients with hyperthyroidism during pregnancy can gradually improve thyroid function under the treatment of propylthiouracil, and it can also reduce the incidence of other symptoms during pregnancy and abnormal conditions in neonates.